TEI-9826 (7) is a prostaglandin analogue that shows high activity against cisplatin-resistant tumors. 457613-78-4 Order Günter Helmchen of the Universität Heidelberg has devised (Angew. Chem. Int. Ed. PMID:29844565 817562-90-6 supplier…
A recent publication by Helen E. Blackwell and co-workers from the University of Wisconsin-Madison (Org. 1251013-26-9 Chemscene Lett. PMID:36717102 2004, 6, 2019. DOI: 10.1021/ol049313f) reports the multistep synthesis of a…
Carbon-carbon bond construction is the basis for all of organic chemistry. Important methods for the construction of single, double, and triple bonds have been described. While ketones can be prepared…
The opening of epoxides by ketone enolates is notoriously difficult. Marie E. Krafft of Florida State University has found (Chem. Commun. 2006, 2977. DOI: 10.1039/b603510h)a simple solution to this problem.…
Blepharocalyxin D (3), isolated from the seeds of Alpinia blepharocalyx, shows antiproliferative activity against murine colon 36-L5 carcinoma in cell culture. A key step in the first synthesis of 3,…
Charles M. Garner of Baylor University has described (Tetrahedron Lett. 2006, 47, 7405. DOI: 10.1016/j.tetlet.2006.08.069)the fragmentation of alcohols such as 1 to give the ketone2. The alcohols are prepared by…
The controlled construction of extended arrays of stereogenic centers is one of the central challenges of organic synthesis. Fmoc-D-His(Trt)-OH In stock One of the earliest methods to become available, and…
There have been much discussion of the benefits of microwave irradiation. C. Oliver Kappe of the University of Graz, among others, has undertaken detailed studies directed toward rationalizing the many…
Since the discovery of L-proline-catalysed reactions, this unique amino acid as been extensively studied as an organocatalyst. Proline has a rigid ring structure, which leads to its special role as…
Efficient new methods for the construction of C-C single, double and triple bonds have recently been reported. Erick M. Carreira of ETH Zurich has developed (Angew. Chem. 737790-46-4 site Int.…
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