Enantiomerically-pure carbocycles can be prepared either de novo, or by desymmetrization of prochiral rings. A classic illustration of the latter approach is the condensation of cyclohexanone (1) with p-nitrobenzaldehyde (2).…
Homoallylic secondary alcohols such as 1 are readily prepared in enantiomerically-pure form by enantioselective addition of allyl anions to the aldehyde. Subhas Chandra Roy of the Indian Association for the…
The Strecker synthesis is the one-carbon homologation of an aldehyde to the α-amino nitrile. Robert Cunico of Northern Illinois University in DeKalb reports (Tetrahedron Lett. 2003, 44, 8025.DOI: 10.1016/j.tetlet.2003.09.006)a modified…
Keiji Maruoka of Kyoto University has developed highly selective catalysts for the alkylation of protected glycine anions. PMID:23600560 He has now shown (J. Am. Chem. Soc. 2005, 127, 5073.DOI: 10.1021/ja0459328)that…
Aryl amines are common constituents of pharmaceuticals, so there has been a great deal of interest in their preparation, e.g by Pd- or Cu-mediated amination of aryl halides. Multi-step procedures…
Alkene metathesis (“Grubbs Reaction”) is now well-developed as a synthetic method. Still, there is a continuing effort to develop more efficient catalysts, and to extend the range of substrates that…
Selective halogenation can be a direct route to high value added materials from inexpensive hydrocarbons. José Barluenga of the Universidad de Oviedo has developed (Angew. Chem. Int. Ed. PMID:23514335 2005,…
Richard P. Hsung, now of the University of Wisconsin, has reported (Org. Lett. 2006, 8, 231. Formula of 2-Hexyloctanoic acid Methyl 6-chloro-5-formylpicolinate site DOI: 10.1021/ol052487s)the intramolecular addition of ynamides to…
Convergent coupling of a nucleophile with an aldehyde ideally will proceed with high enantioselectivity, while at the same time allowing the attachment of a usefully functionalized fragment. Several recently-reported aldehyde…
Powerful methods for the stereocontrolled construction of cyclic ethers have recently been developed, enabling the synthesis of a variety of complex natural products. Many of the Annonaceous acetogenins, represented by…
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