E PD. Evidence that siRNAs function as guides, not primers, from the Drosophila and human RNAi pathways. Mol Cell. 2002;ten:537?8. Thomson DW, Bracken CP, Goodall GJ. Experimental strategies for microRNA…
At both the H53A and H53D mutants showed dTMP formation with dramatically decreased activity (Table S2 of reference 17).Benefits and DiscussionWe have crystallized and solved the structures of H53D mutant…
B (de la Pradilla), Sanguiin H-5 (Spring), Solandelactone A (White), Spirastrellolide A (Paterson) Richard J. K. Taylor of the University of York has developed (Angew. Buy2422999-74-2 Chem. Int. Ed. PMID:23892407…
Products such as 3 and 6 are usually prepared by phosphonate condensation. J. S. PMID:23756629 Yadav of the Indian Institute of Technology, Hyderabad found (Tetrahedron Lett. 2008, 49, 4498. DOI:…
(-)-Ushikolide A (4), isolated from a culture broth of Streptomyces sp. IUK-102, showed powerful activity against murine splenic lymphocyte proliferation (IC50 = 70 nM). The most important player in the…
There are currently 61 known vibsane-type diterpenes, as exemplified by (-)-5-epi-Vibsanin E (3). The first synthesis of 3, described (J. Price of 79208-84-7 Am. Chem. Soc. 2009, 131, 8329. DOI:…
The total synthesis of Epothilone B (4), the first natural product (with Epothilone A) to show the same microtubule-stabilizing activity as paclitaxel (Taxol®), has attracted a great deal of attention…
Conjugate addition-enolate trapping, a strategy originally developed by Gilbert Stork, has become a powerful method for stereocontrolled ring construction. A key step in the synthesis of (-)-Clavirolide C (3) reported…
The enantioselective addition of allyl organometallics to carbonyls has become one of the workhorses of organic synthesis. PMID:24318587 Dennis Hall of the University of Alberta reports (J. Am. Chem. Soc.…
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