(+)-Superstolide A (3), isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at ~ 4 ng/mL concentration. The key transformation in the synthesis of…
Ome 22 (nucleotide 17,049,3907,056,254, 6,865 bp, GEO accession quantity for the aCGH is GEO: GSE89191; Supplementary Information). These cytogenetic observations helped interpret quantitative measurements of codon 707 mutations by dPCR.…
Es (, , and MSH) are a loved ones of peptide hormones that regulate skin pigment cells and impact a array of other processes within the physique, including decreasing inflammation…
A recent publication by the group of Phil S. Baran from the Scripps Research Institute (Angew. Formula of 3-Vinylthiophene Chem. Int. Ed. PMID:24268253 2004, 43, 2674. DOI: 10.1002/anie.200453937) reports the…
(+)-Discodermolide (3), a potent anticancer agent that works synergistically with taxol, may yet prove to be clinically effective. For the synthetic material to be affordable, a highly convergent synthesis is…
The sulfate (+)-didemniserinolipid B (3), isolated from the tunicateDidemnum sp, has an intriguing spiroether core. 1-Bromo-2-fluorobenzene Chemscene A key step in the synthesis of 3 reported (Org. PMID:25046520 Lett. 1031967-52-8…
The tetracyclic Lycopodium alkaloid fawcettimine (3) and its derivatives are of interest as inhibitors of acetylcholine esterase. F. Dean Toste of the University of California, Berkeley recently reported (Angew. Chem.…
(-)-Cernuine (3) falls in the subset of the Lycopodium alkaloids that feature a bicyclic aminal core. There had not been a total synthesis of this class of alkaloids until the…
The direct functionalization of a C-H bond is a powerful transformation for organic synthesis, allowing the rapid elaboration of desired complexity from inexpensive starting materials. Formula of (3-Hydroxy-5-methylphenyl)boronic acid Even…
A classic strategy for controlling relative stereocontrol is to imbed the stereogenic centers in a ring. PMID:23415682 Hisashi Yamamoto of the University of Chicago has developed (J. Am. Chem. Soc.…
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