Although methods both for reduction and for oxidation are well developed, there is always room for improvement. PMID:24059181 While ketones are usually reduced using metal hydrides, hydrogen gas is much…
Mohammad Navid Soltani Rad of Shiraz University of Technology has shown (Tetrahedron Lett. 2007, 48, 6779.DOI: 10.1016/j.tetlet.2007.07.091)that with tosylimidazole (TsIm) activation in the presence of NaCN, primary, secondary and tertiary…
The group of Christian Wolf from Georgetown University, Washington, has reported on the synthesis of benzophenone and acetophenone derivatives via the Suzuki-type cross-coupling of aromatic and aliphatic acyl chlorides with…
An impressive array of new catalysts for enantioselective homologation have been reported. Carlos F. Barbas III of Scripps/La Jolla has found (Angew. Chem. Int. Ed. 2007, 46, 5572. DOI: 10.1002/anie.200701269)that…
The group of Peter Andreana from Wayne State University, Michigan, has developed a one-pot two-step synthesis of regiochemically differentiated 1,4-benzodiazepin-3-ones (Org. PMID:24633055 Lett. 2008, 10, 4541. (6S)-Hexahydro-1,4-oxazepin-6-ol In stock DOI:…
An extensive optimization study toward the synthesis of 6-heterocyclic substituted 2-aminoquinolines via Buchwald-Hartwig amination of 6-bromo-2-chloroquinoline withcyclic amines was conducted by the group of Simon Pyke from the University of…
Phagy inhibition. Autophagy is upregulated in response to erlotinib in NSCLC cell lines and combined therapy with chloroquine, an antimalarial that inhibits autophagy, enhances erlotinib sensitivity (Li, Lam, Mak, Zheng,…
Ere processed in parallel. A few sections wereAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptMol Neurobiol. Author manuscript; obtainable in PMC 2017 July 20.Sharma et al.Pagecounterstained with Haematoxylin-Eosin for great…
John Verkade and Steven Raders from Iowa State University have reported on the synthesis of diaryl ethers by the reaction of electron deficient aryl fluorides with variousTBDMS-protected phenols (Tetrahedron Lett.…
In the chemistry described below, Coats and a group of researchers from Johnson and Johnson utilized successive reductive aminations and Suzuki cross coupling reactions to prepare a 192-member library of…
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