Asymmetric Nucleophilic Epoxidation
Chemexpress Asymmetric epoxidation of a prochiral alkene is an appealing process because two stereogenic centers are established in the course of the reaction. Often, the starting alkene is inexpensive. 1203499-17-5 Order…
The Rawal Synthesis of N-Methylwelwitindolinone D Isonitrile
The complex polycyclic structure of N-Methylwelwitindolinone D Isonitrile (3) was assigned in 1999. The welwitinines show an intriguing range of biological activity, including reversal of P-glycoprotein-mediated multidrug resistance in human…
The Bradshaw/Bonjoch Synthesis of (-)-Anominine
The Hajos-Parrish cyclization was a landmark in the asymmetric construction of polycarbocyclic natural products. PMID:24220671 Impressive at the time, the proline-mediated intramolecular aldol condensation proceeded with an ee that was…
The Boger Synthesis of (-)-Vindoline
The periwinkle-derived alkaloids vinblastine (2a) and vincristine (2b) are still mainstays of cancer chemotherapy. The more complex half of these dimeric alkaloids, vindoline (1), presents a formidable challenge for total…
Nt bone marrow-derived cells inside the improvement of atherosclerosis within this
Nt bone marrow-derived cells inside the development of atherosclerosis within this model . In contrast, transplantation of bone marrow from Tlr42/2 mice into Ldlr2/2 recipients, followed by feeding a high-cholesterol,…
Nhibitor II (40 nM); or MAPK inhibitor PD98059 (50 lM) for 1 hour at
Nhibitor II (40 nM); or MAPK inhibitor PD98059 (50 lM) for 1 hour at 378C. HCEC chemotaxis was measured in response to the buffer control (0.1 BSA in Gey’s buffer);…
The Li/Yang Synthesis of (±)-Maoecrystal V
Maoecrystal V (3), isolated from the Chinese medicinal herb Isodon eriocalyx, shows selective inhibition of HeLa cells at low nanomolar concentration (IC50 = 60 nm). 6-(Diphenylphosphino)-2,2′-bipyridine In stock Chuang-Chuang Li…
The Overman Synthesis of (-)-Actinophyllic Acid
(-)-Actinophyllic Acid (3), isolated from Alstonia actinophylla, is a promising inhibitor of TAFIa/hippicuricase (0.84 µm). Larry E. Overman of UC Irvine envisioned (J. Am. Chem. 4-Aminomethylbenzylalcohol Price Soc. 2010, 132,…
The Garg Synthesis of (±)-Aspidophylline A
The pentacyclic Apocynaceae alkaloid Aspidophylline A (3) was shown to reverse drug resistance in resistant KB cells. In developing a strategy for the assembly of 3, Neil K. PMID:25804060 Garg…
The Funk Synthesis of (-)-Nakadomarin A
The Z alkene of Nakadomarin A (3) suggested to Raymond L. Funk an approach (Org. Lett. 2010, 12, 4912. DOI: 10.1021/ol102079z) based on ring-closing alkyne metathesis. The efficient assembly of…