Heteroaromatics: The Cho Synthesis of Tubifolidine
Chemexpress Antonio J. Moreno-Vargas of the Universidad de Sevilla drove the retro Diels-Alder disassembly of the 7-oxanorbornadiene 1 by reacting it selectively with benzyl azide, leading to the furan 2 (J.…
Diels-Alder Cycloaddition: Lepadin F (Chen), Lammelodysidine A (Molga/ Mlynarski/Grzybowski/Mrksich), Cannogenol (Nakazaki),
cis-crotonin (Cai), Salvinorin A (Metz), Cephanolide A (Sarpong) Lepadin F (4), isolated from the tunicate Didemnum sp, showed antiplasmodial and antitrypanosomal activity. Xiaochuan Chen of Sichuan University prepared the precursor…
Reduction: The Zhai Synthesis of Conidiogenone
Julian G. West of Rice University observed high diastereoselectivity in the reduction of the cyclic alkene 1 to 2 (J. Am. Chem. Soc. 2020, 142, 19316. DOI: 10.1021/jacs.0c09544). Christopher J.…
Cobalt Carbonyl-Mediated Synthesis of Ureas
Mats Larhed and co-workers from Uppsala University (Tetrahedron Lett. 5-Hydroxymethylfurfural Chemscene 2005, 46, 3335. DOI: 10.1016/j.tetlet.2005.03.076)have reported on a novel and very fast gas-free carbonylation method for the preparation of…
Alkylated Sterogenic Centers: The Nagamitsu Synthesis of Habiterpenol
Chihui An and Megan H. Shaw of Merck Process achieved high ee in the reduction of the α-methylene acid 1 to the α-methyl acid 2 (Org. Lett. 2020, 22, 8320.…
(TMS)3SiH in organic synthesis: Part 1
The radical chemistry associated with organosilanes has been the subject of my recent book (Chatgilialoglu C. Organosilanes in Radical Chemistry; Wiley: Chichester, 2004). 7-Chloropyridopyrazine In stock In particular, the use…
Total Synthesis of Ingenol
The total synthesis of the tetracyclic Euphorbia tetraol ingenol 3 reported by Keiji Tanino of Hokkaido University (J. Am. Chem. Soc. PMID:23290930 (1-Methyl-1H-imidazol-2-yl)methanamine web 2003, 125, 1498.DOI: 10.1021/ja029226n)illustrates the power…
Synthesis of (-)-Podophyllotoxin
(-)-Podophyllotoxin 1 and its derivative etoposide 2, derived from natural sources, are in current clinical use. 1239319-91-5 site Michael Sherburn of Australian National University reports (J. Am. PMID:23543429 Chem. Soc.…
Total Synthesis of Ingenol
The total synthesis of the tetracyclic Euphorbia tetraol ingenol 3 reported by Keiji Tanino of Hokkaido University (J. PMID:28630660 Am. 6-Fluoro-2,3-dihydrobenzofuran site Chem. 2832911-62-1 Data Sheet Soc. 2003, 125, 1498.DOI:…
(TMS)3SiH in organic synthesis: Part 1
The radical chemistry associated with organosilanes has been the subject of my recent book (Chatgilialoglu C. Organosilanes in Radical Chemistry; Wiley: Chichester, 2004). PMID:24605203 In particular, the use of(TMS)3SiH in…