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Organocatalyzed C-C Ring Construction: The Takao Synthesis of Puraquinonic Acid

Chemexpress April 1, 2024 0 Comments

Xiaoxia Ye of Wenzhou Medical University and Jun Jiang of Wenzhou University used the barium salt of proline to direct the aldol reaction of the prochiral cyclobutanone 1 with the…

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Functional Group Interconversion: The Salom-Roig Synthesis of α-Conhydrine

Chemexpress April 1, 2024 0 Comments

Kwihwan Park, Tsuyoshi Yamada, and Hironao Sajiki of Gifu Pharmaceutical University devised conditions for the exchange of the allylic alcohol 1 with D2O, to give the trideuterated allylic alcohol 2…

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C-H Functionalization: The Gui Synthesis of Phomarol

Chemexpress April 1, 2024 0 Comments

Yiyun Chen of the Shanghai Institute of Organic Chemistry used the benziodoxole reagents 2 and 3 to convert the activated oxime 1 to the alkyne 4 (Org. Lett. 2022, 24,…

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Enantioselective Construction of Aldol Products: Part Two of Two

Chemexpress April 1, 2024 0 Comments

Acyclic stereoarrays are important both in themselves and as precursors to enantiomerically-defined ring systems. Although the aldol condensation has for many years been a workhorse for acyclic stereoselection, there are…

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C-C Bond Construction: The Li/She Synthesis of Pharbilinic Acid

Chemexpress April 1, 2024 0 Comments

Burkhard König of University Regensburg observed significant diastereoselectivity in the conversion of the ketone 1 to the aldehyde 2 (Angew. Chem. Int. PMID:30125989 Ed. 2022, 61, e202211578. DOI: 10.1002/anie.202211578). John…

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Organocatalyzed C-C Ring Construction: The Ikeuchi/Tanino Synthesis of Coriamytrin

Chemexpress April 1, 2024 0 Comments

Rong-Jie Chein of the Academia Sinica, Taipei used the known (S)-(thiolan-2-yl) diphenylmethanol benzyl ether to catalyze the Johnson-Corey-Chaykovsky cyclopropanation of the enone 1 with the allylic bromide 2 to give…

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Other Methods for Carbocyclic Construction: 6,11-Epoxyisodaucane (Tanino), Magellanine (Yao), Nemorosonol (Ohyoshi/Kigoshi), Antroalbocin (Kalesse), Cochlearol B (Schindler), Emerione A (Miller)

Chemexpress April 1, 2024 0 Comments

6,11-Epoxyisodaucane (3) was isolated from the liverwort Tritomaria polita. In the course of the synthesis of 3, a key step of which was the decyanative cyclization of the epoxide 1…

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eight(6814):86064. 42. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell

Chemexpress March 31, 2024 0 Comments

eight(6814):86064. 42. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell surface expression of human melanocortin4 receptor mutations related with obesity. J Biol Chem 278(25):229392945. 43. Windahl…

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Ivation from shortterm latency. To confirm that fibroblasts were productively infected

Chemexpress March 31, 2024 0 Comments

Ivation from shortterm latency. To confirm that fibroblasts had been productively infected, viral IE1 expression was validated by fluorescence microscopy (Fig. 1E). Similarly, lytic gene expression was observed when latently…

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Functional Group Protection: The Pronin Synthesis of Quassin

Chemexpress March 31, 2024 0 Comments

Elena V. PMID:32472497 5-Bromo-1,3-thiazole-2-carbaldehyde supplier Gusvskaya of the Universidade Federal de Minas Gerais and Matthias Beller of the Leibniz-Institut für Katalyse e.V. used benzaldehyde to convert the alcohol 1 to…

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2-amino-5-benzyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carbonitrile

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2-amino-4-(difluoromethoxy)-5-methoxybenzoic acid (CAS 923145-68-0)

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D by scaling is closer to the observed rate at 10 C

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C experiments to mimic diagenesis at burial temperature. The outcomes highlighted

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