Nce (SID) was defined as (Na K Ca2 Mg2) (Cl lactate
Chemexpress Nce (SID) was defined as (Na K Ca2 Mg2) (Cl lactate) mEq/L . Hyperchloraemic metabolic acidosis was defined as SID below 40 mEq/L connected with chloraemia above 108 mmol/L in…
Alkyne Metathesis in Organic Synthesis
While alkyne metathesis is not going to displace alkene metathesis as a synthetic method, it is a complementary approach that can offer advantages. Catalysts for alkyne metathesis are still under…
Synthesis of the Proteasome
Inhibitors Salinosporamide A, Omuralide and Lactacystin The structurally-related γ-lactams salinosporamide A (1), omuralide (2) and lactacystin (3), of bacterial origin, inhibit proteasome activity, and so are of interest as lead…
Enantioselective α-Functionalization of Carbonyl Compounds
The enantioselective oxygenation procedures, epoxidation and dihydroxylation, developed by Barry Sharpless have dominated single-enantiomer organic synthesis. Recently, several additional methods for enantioselective oxidation have been developed, based on the α-functionalization…
Enantioselective Allylic Carbon-Carbon Bond Construction
Although many methods have been developed for enantioselective carbon-carbon construction, not all of these are robust and scalable. A promising recent addition has been the development of protocols for the…
Enantioselective Construction of
Arrays of Stereogenic Centers Single enantiomer synthesis is of increasing importance in pharmaceutical production. It is essential that practical and scalable procedures be developed for controlling the absolute configuration of…
Best Synthetic Methods
Benzyl ethers are among the most commonly used protecting groups for alcohols. PMID:23554582 Usually, these are prepared using an excess of NaH and benzyl bromide. Buy1-(Aminomethyl)cyclopentanol Okan Sirkecioglu of Istanbul…
Asymmetric Transformation of Prochiral Carbocyclic Rings
The push toward enantiomerically-purecarbocyclic intermediates has led to the development of new methods for the enantiodifferentiation of inexpensive prochiral cyclic starting materials. For instance, Robert H. Morris of the University…
Enantioselective Sulfoxidation
In the last few years, chiral sulfoxides have become important targets in organic synthesis, and their chemistry has recently been reviewed (Org. Chem. Highlights 2004, December 24. Link). An increasing…
Enantioselective Aza-Henry and Aza-Michael Reactions
The asymmetric conjugate addition is regarded as one of the most powerful tools for the selective formation of chiral C-C or C-X bonds. Particular cases of this methodology are the…