Substituted Benzenes: The Kirsch Synthesis of Cybrodol
Chemexpress Stephen L. Buchwald of MIT established (J. Am. Buy885588-14-7 Chem. Soc. 2010, 132, 14076. DOI: 10.1021/ja107481a) a Pd-catalyzed protocol for conversion of an aryl triflate 1 to the halide 2.…
Organocatalyzed C-C Ring Construction: The Thomson Synthesis of Streptorubin
B Jinxing Ye of the East China University of Science and Technology used (Tetrahedron Lett. PMID:23399686 Formula of 240401-09-6 2011, 52, 2715. DOI: 10.1016/j.tetlet.2011.03.079) the Hayashi catalyst to direct the…
Enantioselective Preparation of Alcohols and Amines: The Lam Synthesis of (+)-Tanikolide
Takashi Ooi of Nagoya University effected (J. Am. Chem. PMID:23847952 Soc. 2010, 132, 12240. DOI: 10.1021/ja105945z) the enantioselective protonation of ketene silyl acetals such as 1 to give 2 in…
C-O Ring Construction: The Theodorakis Synthesis of (-)-Englerin A
Liming Zhang of the University of California, Santa Barbara described (J. Am. Chem. Soc. (R)-2-amino-1-phenylethan-1-ol manufacturer 2010, 132, 8550. DOI: 10.1021/ja1033952) the remarkable transformation of a propargyl alcohol 1 into…
Flow Methods for Organic Synthesis
Carrying out organic synthesis with a flow reactor can offer significant advantages over the more conventional batch processing. Andreas Kirschning of Leibniz Universität Hannover concisely summarized (Chem. Commun. 2011, 47,…
Unction in the NaV1 channel in C. finmarchicus is achieved through
Unction inside the NaV1 channel in C. finmarchicus is accomplished by way of both option splicing and gene duplication. This diversity of transcripts for voltagegated sodium channels helps explain why…
O their matching orthologues within the other tetraploid, G. barbadense (.98 at
O their matching orthologues inside the other tetraploid, G. barbadense (.98 at the aa level). The deduced proteins varied from 514 to 582 amino acids and all clustered within the…
Stereoselective C-O Ring Construction: (+)-Pachastrissamine (Fujii/Ohno),
Aspalathin (Minehan), (+)-Varitriol (Ghosh), Aspercyclide A (Spivey), Etnangien (Menche) (+)-Pachastrissamine (3), also known as Jaspine B, induces apoptosis in melanoma cells by a caspase-dependent pathway. Nobutaka Fujii and Hiroaki Ohno…
Metal-Mediated Carbocyclic Construction: The Simpkins Synthesis of Ialibinones A and B
Adriaan J. Minnaard and Ben L. Feringa of the University of Groningen devised (J. Azido-PEG2-CH2COOH Price Am. Chem. Soc. 2010, 132, 14349. DOI: 10.1021/ja105704m) what promises to be a general…
Alkaloid Synthesis: (+)-Preussin (Britton), (±)-Xenovenine (Livinghouse),
(+)-Subincanadine F (Li), (±)-Strychnine (Reissig), (-)-Virginiamycin M2 (Panek) Aldehydes such as 1 are readily available by direct enantioselective chlorination. Robert Britton of Simon Fraser University found (Org. Lett. 2010, 12,…