Synthesis of 7-Azaindoles
Chemexpress Hartmut Schirok from Bayer HealthCare, Germany, has reported on a short and flexible synthesis of 1,3-substituted 7-azaindoles 2 starting from oxiranes 1 (J. PMID:23724934 Org. Chem. 2006, 71, 5538.DOI: 10.1021/jo060512h).…
Ring Closing Metathesis for Guaianolide Synthesis
Oliver Reiser and his group from the University of Regensburg, Germany have reported on the ring-closing metathesis (RCM) of a sterically demanding substrate in the context of the total synthesis…
Synthesis of Furocoumarin Libraries
A 144-member library of furocoumarins via three-component reaction of 4-hydroxycoumarins, isocyanides and arylaldehydes was prepared by Jie Wu from VivoQuest Inc., NY (Chem. Lett. 2006, 35, 118. (4-Chlorophenyl)(2-nitrophenyl)sulfane web DOI:…
Single-Step Synthesis of Pyrimidine Derivatives
Mohammad Movassaghi and Matthew D. Hill from MIT have developed a protocol for the synthesis of quinazolines 1 via electrophilic activiation of secondary amides utilizing 2-chloropyridine (2-ClPyr) in combination with…
Enzymes in Organic Synthesis
Enzymes have many applications in organic synthesis. One of the most common is the resolution of a secondary alcohol. A shortcoming of this approach is that the separation of the…
Organocatalyzed Asymmetric Reactions
Sarah Mossé and Alexandre Alexakis from the University of Geneva have reinvestigated asymmetric aldol (a), Mannich (b) and Diels-Alder reactions (c) applying organocatalysis under microwave conditions (Org. PMID:23912708 Lett. BuyRuPhos…
Catalyst- and Base-Free Suzuki-Type Coupling
Jie Yan and co-workers from Zhejiang University of Technology, China, have reported on Suzuki-type couplings in water without the use of catalyst and base (Eur. J. PMID:23558135 Org. P(t-Bu)3 Pd…
New Dienes and Dienophiles for Intermolecular and Intramolecular Diels-Alder Cycloadditions
The Diels-Alder reaction is a powerful tool for the construction of substituted cyclohexenes. Erik J. Formula of 1234616-36-4 Sorenson of Princeton University has developed (J. Am. 2-(2-Bromoethyl)oxirane Formula Chem. Soc.…
Stereocontrolled Construction of N-Heterocycles
Yong-Gui Zhou of the Dalian Institute of Chemical Physics (Angew. Chem. PMID:28038441 Int. Ed. 2006, 45, 2260. Pyrimidine-2-carbaldehyde web DOI: 10.1002/anie.200503073)and Manfred T. Reetz of the Max-Planck-Institut, Mülheim (Chem. Commun.…
Best Synthetic Methods: Carbon-Carbon Bond Formation
Carbon-carbon bond formation is central to organic synthesis. In the ideal, a homologation method will start with a common functional group, and proceed under mild conditions using non-toxic reagents. These…