The Rychnovsky Synthesis of Leucascandrolide A
Chemexpress The macrolactone leucascandrolide A (4), isolated from the calcareous sponge L. caveolata, has both cytotoxic and antifungal activity. The key step in the synthesis of 4 reported (J. Org. Chem.…
The Maier Synthesis of Cruentaren A
Cruentaren A (3), isolated from the myxobacterium Byssovorax cruenta, is an inhibitor of mitochondrial F-ATPase. The synthesis of 3 (Org. Lett. 2007, 9, 655, DOI: 10.1021/ol0629317; Angew. Chem. Int. Ed.…
The Ley Synthesis of Rapamycin
Rapamycin (3) is used clinically as an immunosuppressive agent. The synthesis of 3 (Angew. N-(2-Hydroxyethyl)maleimide Data Sheet Chem. Int. PMID:35345980 Morpholin-2-one site Ed. 2007, 46, 591.DOI: 10.1002/anie.200604053)by Steven V. Ley…
The Roush Synthesis of (+)-Superstolide A
(+)-Superstolide A (3), isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at ~ 4 ng/mL concentration. The key transformation in the synthesis of…
Ome 22 (nucleotide 17,049,3907,056,254, six,865 bp, GEO accession number for the aCGH is GEO
Ome 22 (nucleotide 17,049,3907,056,254, 6,865 bp, GEO accession quantity for the aCGH is GEO: GSE89191; Supplementary Information). These cytogenetic observations helped interpret quantitative measurements of codon 707 mutations by dPCR.…
Es (, , and MSH) are a family of peptide hormones that regulate
Es (, , and MSH) are a loved ones of peptide hormones that regulate skin pigment cells and impact a array of other processes within the physique, including decreasing inflammation…
Vinyl Cyclobutane Rearrangements
A recent publication by the group of Phil S. Baran from the Scripps Research Institute (Angew. Formula of 3-Vinylthiophene Chem. Int. Ed. PMID:24268253 2004, 43, 2674. DOI: 10.1002/anie.200453937) reports the…
The Betzer and Ardisson Synthesis of (+)-Discodermolide
(+)-Discodermolide (3), a potent anticancer agent that works synergistically with taxol, may yet prove to be clinically effective. For the synthetic material to be affordable, a highly convergent synthesis is…
The Burke Synthesis of (+)-Didemniserinolipid B
The sulfate (+)-didemniserinolipid B (3), isolated from the tunicateDidemnum sp, has an intriguing spiroether core. 1-Bromo-2-fluorobenzene Chemscene A key step in the synthesis of 3 reported (Org. PMID:25046520 Lett. 1031967-52-8…
The Toste Synthesis of (+)-Fawcettimine
The tetracyclic Lycopodium alkaloid fawcettimine (3) and its derivatives are of interest as inhibitors of acetylcholine esterase. F. Dean Toste of the University of California, Berkeley recently reported (Angew. Chem.…