Secondary alcohols can be prepared in high enantiomeric excess by catalytic hydrogenation of ketones. Zhaoguo Zhang of Shanghai Jiaotong University has established (Org. Lett. 2007, 9, 5613. DOI: 10.1021/ol702565x)that β-keto…
As alkene metathesis has developed into one of the tools of organic synthesis, many practical questions have arisen. Mc-Val-Cit-PABC-PNP supplier In the course of a synthesis (Org. Lett. 2007, 9,…
Several methods have been reported for the stereocontrolled preparation of pyrrolidine and piperidine derivatives. Alison J. Frontier of the University of Rochester has observed (Org. Lett. 2007, 9, 4939.DOI: 10.1021/ol701962w)that…
François Morvan of the Université de Montpellier, using the inexpensive dimethyl phosphite, optimized (Tetrahedron Lett. 2008, 49, 3288. DOI: 10.1016/j.tetlet.2008.03.079)the free radical reduction of 1 to 2. BuycataCXium Pd G4…
Although the enantioselective oxidation of alkyl aryl sulfides is well developed, much less is known about dialkyl sulfides. Tsutomu Katsuki of Kyushu University has designed (J. Am. Chem. Soc. PMID:26446225…
Oxygenated secondary stereogenic centers are readily available. There is a limited range of carbon nucleophiles that will displace a secondary leaving group in high yield with clean inversion. Teruaki Mukaiyama…
Powerful methods for catalytic, enantioselective intermolecularDiels-Alder reactions have been developed. Ben L. Feringa and Gerard Roelfes of the University of Groningen have shown (Org. PMID:23453497 Lett. 2007, 9, 3647. DOI:…
A recent publication by Nicholas J. PMID:26644518 Buy3-Azidopropylamine Turner and co-workers from the University of Edinburgh (J. Org. Chem. benzene Formula 2004, 69, 6920.DOI: 10.1021/jo049132r)describes the microwave-assisted palladium-catalyzed cross-coupling of…
The power of catalytic C-H functionalization is illustrated by the elegant synthesis of rhazinicine (3) devised (Angew. Chem. PMID:34235739 Int. Ed. 2008, 47, 3004. DOI: 10.1002/anie.200705005)by Matthew J. Propargyl-PEG1-NHS ester…
Alkenes are usually reduced by catalytic hydrogenation. Diimide reduction is a mild and neutral alternative. Keith R. Buszek, now at the University of Missouri, Kansas City, has shown (J. Org.…
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