Stilbene diols such as 3 are gaining prominence both as synthetic intermediates and as effective chiral auxiliaries. While the diols can be prepared in high ee by Sharpless dihydroxylation, it…
Centration-dependent manner (Figure 3D, ideal) that peaked 24 hours immediately after the commence of treatment.5-FU Effects on Pim-1 Expression Are Mediated by miR-15bTo address the 5-FU ediated up-regulation of Pim-1…
Synthesis of (-)-Lasiol Hisashi Yamamoto of the University of Chicago devised (J. Am. Chem. Soc. 2010, 132, 7878. DOI: 10.1021/ja100951u) catalyst systems for the enantioselective epoxidation of a Z-homoallylic alcohol…
Stephen L. Buchwald of MIT established (J. Am. Buy885588-14-7 Chem. Soc. 2010, 132, 14076. DOI: 10.1021/ja107481a) a Pd-catalyzed protocol for conversion of an aryl triflate 1 to the halide 2.…
We found (Tetrahedron Lett. PMID:36014399 2010, 51, 3545. DOI: 10.1016/j.tetlet.2010.04.129) that the superiority of KH over NaH in the Williamson ether synthesis was particularly marked with congested partners such as…
B Jinxing Ye of the East China University of Science and Technology used (Tetrahedron Lett. PMID:23399686 Formula of 240401-09-6 2011, 52, 2715. DOI: 10.1016/j.tetlet.2011.03.079) the Hayashi catalyst to direct the…
Takashi Ooi of Nagoya University effected (J. Am. Chem. PMID:23847952 Soc. 2010, 132, 12240. DOI: 10.1021/ja105945z) the enantioselective protonation of ketene silyl acetals such as 1 to give 2 in…
Liming Zhang of the University of California, Santa Barbara described (J. Am. Chem. Soc. (R)-2-amino-1-phenylethan-1-ol manufacturer 2010, 132, 8550. DOI: 10.1021/ja1033952) the remarkable transformation of a propargyl alcohol 1 into…
Carrying out organic synthesis with a flow reactor can offer significant advantages over the more conventional batch processing. Andreas Kirschning of Leibniz Universität Hannover concisely summarized (Chem. Commun. 2011, 47,…
Unction inside the NaV1 channel in C. finmarchicus is accomplished by way of both option splicing and gene duplication. This diversity of transcripts for voltagegated sodium channels helps explain why…
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