The Carreira Synthesis of Euphorikanin A
Chemexpress Euphorikanin A (3), isolated from the roots of the Chinese succulent herb Euphorbia kansui, showed the ability to reactivate latent HIV. En route to 3, Erick M. PMID:25959043 Carreira of…
The Rawal Synthesis of Heilonine
Helionine (3) was isolated from the Chinese lily Fritillaria ussuriensis, used in traditional medicine. Viresh H. Buy1,3,5-Tri(pyridin-4-yl)benzene Rawal of the University of Chicago devised a convergent approach to 3, based…
The Dong Synthesis of Phainanoid A
Phainanoid A (3), isolated from the shrub Phyllanthus hainanensis Merr., found only on Hainan Island, showed both promising toxicity against cancer cell lines, and immunosuppressive activity. Guangbin Dong of the…
C-H Functionalization: The Baran Synthesis of Maximiscine
Jie Wu of Taizhou University prepared the vinyl sulfone 3 by coupling the tertiary propargylic alcohol 1 with the diazonium salt 2 in the presence of sodium metabisulfite (Adv. Synth.…
Ethylene-Alkyne Cross-Metathesis
Maurizio Botta and his group from the University of Siena, Italy have employed microwave mediated ethylene-alkyne cross-metathesis using Grubbs 2 catalyst for the synthesis of enantioenriched 2-substituted butadiens (Tetrahedron: Asymmetry…
Organocatalyzed C-C Ring Construction: The List Synthesis of 2-epi-ziza-6(13)-en-3-one
Gullapalli Kumaraswamy of the Indian Institute of Chemical Technology assembled the cyclopropane 3 by the (DHQD) Pyr-mediated addition of the bromo amide 2 to the enone 1 (Tetrahedron 2021, 87,…
Other Methods for Carbocyclic Construction: COTC (Buda), Brussonol (Jin/Qiu), Lingzhiol (Luo/Qin), Melicolone A (Martin), Macfarlandin C (Overman),
Mitrephorone A (Carreira) The crotonate ester COTC (3), an inhibitor of alkaline phosphodiesterase isolated from a soil Streptomyces, had cytotoxic and cancerostatic activity. Szymon Buda of Jagiellonian University prepared the…
Antibody (Abcam; Ab13509; 1:200) or perhaps a standard rabbit IgG (Santa Cruz Biotechnology
Antibody (Abcam; Ab13509; 1:200) or even a standard rabbit IgG (Santa Cruz Biotechnology; 1:100) was incubated using the cell lysate and with 40 L protein A agarose beads (Roche). The…
Occupy the complementary S4 and S1 subsites, respectively. Acidic residues are
Occupy the complementary S4 and S1 subsites, respectively. Acidic residues are shown in orange; Glu79 at the P2 position and Glu85 in the P4 position are close to CTRC regions…
D CTRC Ser214 (Ser236) (Fig. 2C). The Leu45 carbonyl oxygen is
D CTRC Ser214 (Ser236) (Fig. 2C). The Leu45 carbonyl oxygen is positioned to interact with the CTRC oxyanion hole amide nitrogens of Ser195 (Ser216) and Gly193 (Gly214). Around the primed…