C-O Ring Construction: The Fuwa Synthesis of Exiguolide
Chemexpress Arjan W. Kleij of ICIQ optimized an aluminum catalyst for the conversion of the bis epoxide 1 to the oxetane 2 (ACS Catal. PMID:23399686 2022, 12, 5464. DOI: 10.1021/acscatal.2c00925). A.…
The Jia Synthesis of Aberrarone
The tetraketone aberrarone (3), isolated from the feathery Caribbean gorgonian Pseudopterogorgia elisabethae, shows in vitro activity against the malaria parasite. Yanxing Jia of Peking University devised a route to 3…
The Barriault Synthesis of Ginkgolide C
The ginkgolides, in particular ginkgolide B, lacking the OH at C-7, are potent antagonists of platelet-aggregating acceptor (PAFR). PMID:24275718 Louis Barriault of the University of Ottawa described the first synthesis…
The Ding Synthesis of Crinipellin F
The crinipellins are the only tetraquinane natural products. The enone crinipellins have anticancer activity. Hanfeng Ding of Zhejiang University devised a general route to the crinipellins, illustrated by crinipellin F…
The Luo Synthesis of Triptonide
Triptonide (3), isolated from the Chinese herb Tripterygium Wilfordii Hook F, displays reversible male contraceptive effects in both mice and monkeys. A key step in the synthesis of 3 by…
1 or 3 h, respectively, at four Bioinformatic analysis of AAV genome folding type
1 or 3 h, respectively, at 4 Bioinformatic analysis of AAV genome folding form The putative ssAAV and scAAV genome folding form and hybridization prediction were investigated (http://mfold. rna.albany.edu/q=mfold/DNAFoldingForm). The…
Ced cell proliferation, migration, and/or invasion of endometriotic and endometrial
Ced cell proliferation, migration, and/or invasion of endometriotic and endometrial cells of sufferers with endometriosis. To date, several components have been identified that target unique actions within the Wnt/catenin pathway…
The Trauner Synthesis of Tetrodotoxin
Tetrodotoxin (4), the lethal principle of pufferfish (and some salamanders!) is a highly-substituted cyclohexane. Buy2179072-33-2 Dirk Trauner of the University of Pennsylvania assembled the intermediate cyclohexane 3 via an intramolecular…
Enantioselective Construction of Oxygenated and Halogenated Secondary Stereocenters
High ee halogenated secondary centers and, via activation, oxygenated secondary centers are requisite intermediates for the preparation of enantiomerically-pure natural products and pharmaceuticals. Several methods have recently been reported for…
The Renata Synthesis of Gedunin
Gedunin (3), isolated from the Indian neem tree Azadirachta indica, modulates the activity of Hsp90. PMID:23907051 En route to 3, Hans Renata of Rice University devised the diastereoselective H-atom transfer…