C-H Functionalization: The Gui Synthesis of Phomarol
Chemexpress Yiyun Chen of the Shanghai Institute of Organic Chemistry used the benziodoxole reagents 2 and 3 to convert the activated oxime 1 to the alkyne 4 (Org. Lett. 2022, 24,…
Enantioselective Construction of Aldol Products: Part Two of Two
Acyclic stereoarrays are important both in themselves and as precursors to enantiomerically-defined ring systems. Although the aldol condensation has for many years been a workhorse for acyclic stereoselection, there are…
C-C Bond Construction: The Li/She Synthesis of Pharbilinic Acid
Burkhard König of University Regensburg observed significant diastereoselectivity in the conversion of the ketone 1 to the aldehyde 2 (Angew. Chem. Int. PMID:30125989 Ed. 2022, 61, e202211578. DOI: 10.1002/anie.202211578). John…
Organocatalyzed C-C Ring Construction: The Ikeuchi/Tanino Synthesis of Coriamytrin
Rong-Jie Chein of the Academia Sinica, Taipei used the known (S)-(thiolan-2-yl) diphenylmethanol benzyl ether to catalyze the Johnson-Corey-Chaykovsky cyclopropanation of the enone 1 with the allylic bromide 2 to give…
Other Methods for Carbocyclic Construction: 6,11-Epoxyisodaucane (Tanino), Magellanine (Yao), Nemorosonol (Ohyoshi/Kigoshi), Antroalbocin (Kalesse), Cochlearol B (Schindler), Emerione A (Miller)
6,11-Epoxyisodaucane (3) was isolated from the liverwort Tritomaria polita. In the course of the synthesis of 3, a key step of which was the decyanative cyclization of the epoxide 1…
eight(6814):86064. 42. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell
eight(6814):86064. 42. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell surface expression of human melanocortin4 receptor mutations related with obesity. J Biol Chem 278(25):229392945. 43. Windahl…
Ivation from shortterm latency. To confirm that fibroblasts were productively infected
Ivation from shortterm latency. To confirm that fibroblasts had been productively infected, viral IE1 expression was validated by fluorescence microscopy (Fig. 1E). Similarly, lytic gene expression was observed when latently…
Functional Group Protection: The Pronin Synthesis of Quassin
Elena V. PMID:32472497 5-Bromo-1,3-thiazole-2-carbaldehyde supplier Gusvskaya of the Universidade Federal de Minas Gerais and Matthias Beller of the Leibniz-Institut für Katalyse e.V. used benzaldehyde to convert the alcohol 1 to…
Functional Group Interconversion: The Hirose/Sunazuka Synthesis of Luminamicin
Qiao-qiao Teng and Ming Chen of Changzhou University showed that barium oxide is a strong enough base to doubly deuterate an alkyl nitrile 1, leading to 2 (Eur. J. 1196154-13-8…
Arrays of Stereogenic Centers: The Liu Synthesis of Shizukaol J
Shyam Sathyamoorthi of the University of Kansas showed that the epoxide 1 could be cyclized to the differentially-protected triol 2 (Org. Lett. 2022, 24, 939. DOI: 10.1021/acs.orglett.1c04310). David J. Aitken…