Heterocycle Construction by Grubbs Metathesis
Chemexpress Grubbs metathesis has proven to be a powerful tool for the rapid construction of complex heterocycles. Shengming Ma of the the Shanghai Institute of Organic Chemistry reports (J. Org. Methyl…
Other Methods for Carbocyclic Construction: Piperarborenine B (Antonchick), Nakafuran-8 (Houk/Li), Cochlearol B (Sugita), Talatisamine (Reisman), Berkeleyone A (Li), Prostratin (Inoue)
Piperarborenine B (3), isolated from the stem of Piper arborescens, shows significant and selective antineoplastic activity. 2-(4,4-Difluorocyclohexyl)acetic acid site Andrey P. Antonchick of Nottingham Trent University constructed the cyclobutane core…
Are plated at a density of 16105 and quantified at every day intervals.
Are plated at a density of 16105 and quantified at day-to-day intervals. (E) Statistical analyses (n 3 independent samples per experiment) show that the numbers of cells per unit location…
As loading control the expression of vinculin was usedkinase AKT (Figures
As loading handle the expression of vinculin was usedkinase AKT (Figures 3 and 8c);47,48 and ERO1L expression, which controls the apoptotic process by escalating ROS levels and potentiating calcium release.49,50…
Reduction: The Ogawa Synthesis of Maresin 2
Zheng Huang of the Shanghai Institute of Organic Chemistry showed that with an Ir catalyst, ethanol could serve as a reducing medium for the conversion of the alkyne 1 to…
Organocatalyzed C-C Ring Construction: The Gleason Synthesis of 3-Oxoisotaxodione
Hai-Chao Xu of Xiamen University used a phenothiazine-based catalyst to mediate the oxidative cyclization of the amide 1 to the cyclopropane 2 (J. Am. Chem. Soc. 2022, 144, 2343. DOI:…
Functional Group Interconversion: The Wang Synthesis of Spirojatamol
Daniele Leonori, now at RWTH Aachen University, employed visible light to promote the Co-catalyzed elimination of the primary bromide 1 to the alkene 2 (J. 2091009-80-0 site Am. PMID:24211511 Chem.…
Arrays of Stereogenic Centers: The Kalesse Synthesis of Chondrochloren A
Massimo Bietti of the Università "Tor Vergata" and Miquel Costas of the Universtat de Girona achieved substantial diastereoselectivity in the oxidative cyclization of the carboxylic acid 1 to the lactone…
Other Methods for C-C Ring Construction: Melicodenine C(Swierk/Brown), Myrioneurinol (Ma), Pleuromutilin (Pronin), Isorosthin L (Liang), Merrilactone A (Shenvi), Resiniferatoxin (Inoue)
Melicodenine C (4) was isolated from the leaves of Melicope denhamii, a rutaceous shrub found in Borneo that has been used in indigenous medicine. PMID:23892407 John R. Swierk of Binghamton…
Functional Group Protection: The Lee Synthesis of Jujuyane
A. PMID:28739548 Fmoc-Phe-OH Chemscene Venkat Narsaiah of CSIR-Indian Institute of Technology, Hyderabad selectively removed one of the silyl ethers of 1, to give 2 (Tetrahedron Lett. 2021, 82, 153410. DOI:…