Petromyroxol (3) was isolated from > 106 liters of sea water conditioned with larval sea lamprey, Petromyzon marinus. Rodney A. Fernandes of the Indian Institute of Technology Bombay assembled the…
Qiwei Lang, Gen-Qiang Chen and Xumu Zhang of the Southern University of Science and Technology achieved high ee in the reduction of the readily available lactol 1 to the lactone…
Many of the five- and six-carbon sugars, although well known, are rare, and too expensive to be used as chiral pool starting materials. David MacMillan of Caltech in an elegant…
Christopher B. 2-Aminoacetamide uses Kelly of Janssen Discovery Process, Osvaldo Gutierrez of Texas A&M and Mark D. Levin of the University of Chicago used the N-acyloxy N-alkoxy amide 2 to…
Benjamin List of the Max-Planck-Institut für Kohlenforschung used a confined imidodiphosphorimidate to catalyze the cyclization of the unsaturated acid 1 to the lactone 2 (J. Am. Chem. Soc. 2023, 145,…
Kamebanin (3), isolated from the Japanese flowering plant Isodon kameba Okuyama (Isodon umbrosus), showed cytotoxic and antibiotic activity. Takahiro Suzuki and Keiji Tanino of Hokkaido University devised a route to…
Guisheng Zhang and Zhiguo Zhang of Henan Normal University rearranged the activated cyclopropane 1 with catalytic 2, leading to the dihydrofuran 3 (J. Org. PMID:23800738 Chem. 2023, 88, 1003. DOI:…
Cyclopamine (4), a teratogenic alkaloid isolated from the California corn lily Veratrum californicum, has been shown to disrupt the hedgehog signalling pathway. Phil S. Baran of Scripps/La Jolla envisioned a…
Trachinol (3), isolated fifty years ago from Sideritis canariensis Ait., a shrub of the Canary Islands, has an intriguing pentacyclic structure. Chun-An Fan of Lanzhou University devised an elegant preparation…
By C MunozPinedoReovirus induces ER anxiety JS Carew et alsubstantial accrual of ubiquitinconjugated proteins and induced ER stressmediated apoptosis in each in vitro and in vivo models of pancreatic cancer.146…
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