Somewhat related to the well-knownSuzuki cross-coupling reaction involving organoboron reagents, is the so-calledHiyama coupling of organosilanes with halides and triflates to form unsymmetrical biaryl compounds. Seganish and DeShong from the…
The recent (Chem. Commun. 2006, 1968.DOI: 10.1039/b602056a)synthesis of (-)-centrolobine (6) by Siegfried Blechert of the Technische Universität Berlin is a tour de force of organometallic catalysis. The absolute configuration of…
The thermal elimination of aryl sulfoxides is widely used, but requires elevated temperatures. Jun-ichi Matsuo and Hiroyuki Ishibashi of Kanazawa University have now shown (Org. Lett. Price of 168892-66-8 2006,…
Five-membered cyclic ethers often do not show strong thermodynamic preferences. High diastereocontrol can, however, be achieved. Epoxy alkynes such as 1 can be prepared in high ee bySharpless epoxidation. Buy5-Azaspirooctane-6,8-dione…
A variety of effective strategies for catalytic enantioselective ring construction have recently been developed. The simplest approach is to start with a prochiral ring. Yian Shi of Colorado State University…
Ive therapy solutions for patients with osteopenia. Indeed, drug therapy can be a dominant method against no therapy for girls with osteopenia who’re older than 65 years. The truth that…
Ficreports/Figure five. iDPSCs mimic the pharmacological response of DP cells to minoxidil sulfate. (a) Schematic illustrating the experimental procedure along with a pathological image of human hair follicle bulb. A…
Most methods for C-C bond formation involve the coupling of two already-functionalized carbons. Michael P. Doyle of the University of Maryland has developed (J. Am. Chem. Soc. (S)-2-Azido-3,3-dimethylbutanoic acid web…
One of the simplest ways to establish an enantiomerically-pure ternary center is to selectively hydrogenate a trisubstituted alkene. While there are many examples of the enantioselective reduction of more highly…
Direct conversion of an unactivated C-H bond to a C-O, C-N or C-C bond is a powerful way to add valuable complexity to a substrate. While this is by no…
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