Somewhat related to the well-knownSuzuki cross-coupling reaction involving organoboron reagents, is the so-calledHiyama coupling of organosilanes with halides and triflates to form unsymmetrical biaryl compounds. Seganish and DeShong from the…
The recent (Chem. Commun. 2006, 1968.DOI: 10.1039/b602056a)synthesis of (-)-centrolobine (6) by Siegfried Blechert of the Technische Universität Berlin is a tour de force of organometallic catalysis. The absolute configuration of…
The thermal elimination of aryl sulfoxides is widely used, but requires elevated temperatures. Jun-ichi Matsuo and Hiroyuki Ishibashi of Kanazawa University have now shown (Org. Lett. Price of 168892-66-8 2006,…
Five-membered cyclic ethers often do not show strong thermodynamic preferences. High diastereocontrol can, however, be achieved. Epoxy alkynes such as 1 can be prepared in high ee bySharpless epoxidation. Buy5-Azaspirooctane-6,8-dione…
A variety of effective strategies for catalytic enantioselective ring construction have recently been developed. The simplest approach is to start with a prochiral ring. Yian Shi of Colorado State University…
Ive therapy solutions for patients with osteopenia. Indeed, drug therapy can be a dominant method against no therapy for girls with osteopenia who’re older than 65 years. The truth that…
Ficreports/Figure five. iDPSCs mimic the pharmacological response of DP cells to minoxidil sulfate. (a) Schematic illustrating the experimental procedure along with a pathological image of human hair follicle bulb. A…
Most methods for C-C bond formation involve the coupling of two already-functionalized carbons. Michael P. Doyle of the University of Maryland has developed (J. Am. Chem. Soc. (S)-2-Azido-3,3-dimethylbutanoic acid web…
One of the simplest ways to establish an enantiomerically-pure ternary center is to selectively hydrogenate a trisubstituted alkene. While there are many examples of the enantioselective reduction of more highly…
While alkene metathesis has become part of the toolkit of organic synthesis, investigators around the world are pushing the limits of the method as they employ the reaction in total…
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