Reaction with an enantiomerically-pure epoxide is an efficient way to construct a molecule incorporating an enantiomerically-pure oxygenated stereogenic center. The Jacobsen hydrolytic resolution has made such enantiomerically-pure epoxides readily available…
Currently, glycosylation is still a very challenging reaction due to the delicate balance between the reactivity and stereoselectivity. Solid phase synthesis has been recently described as an efficient alternative to…
One of the more powerful routes to enantiomerically-purecarbocycles is the desymmetrization of a prochiral ring. Karl Anker Jørgensen of Aarhus University has found (J. Am. Chem. Soc. 2007, 129, 441.…
Tective effect on DN by using the HFD/STZ induced diabetic rats. We discovered that TP considerably decreased the relative kidney weight, which reflects kidney hypertrophy, and also the 24 h…
Es . A feasible explanation for why ICA flow was drastically associated with amyloid positivity and MCA flow was not is the fact that offered the compact sample size, there’s…
Complex natural products and even some complex pharmaceuticals contain arrays of stereogenic centers. Sometimes, the desired array is readily available from a natural product, but usually, such arrays of multiple…
Benzyl esters are easily deprotected by hydrogenolysis. It is often observed, however, as exemplified by the conversion of 1 to 2 reported (Adv. Synth. Catal. 6-Bromo-4(1H)-cinnolinone Chemical name 2008, 350,…
Jaiwook Park of Pohang University of Science and Technology has developed (Org. Lett. 2007, 9, 3417.DOI: 10.1021/ol701456w)a procedure for the preparation of Pd-impregnated magnetic Fe nanoparticles. This effective hydrogenation catalyst…
The construction of carbon-carbon bonds is fundamental to organic synthesis. PMID:23880095 Recently, three new methods have been reported, each of which has substantial potential for the synthesis of highly functionalized…
Armando Córdova of Stockholm University has found (Tetrahedron Lett. 2008, 49, 4209. DOI: 10.1016/j.tetlet.2008.04.162)that the organocatalyst 3a effected enantioselective conjugate addition of bromonitromethane 2 to the α,β-unsaturated aldehyde 1, to…
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