The Trost Synthesis of (-)-Pseudolaric Acid B
Chemexpress (-)-Pseudolaric Acid B (3), isolated from the bark of the golden larch Pseudolarix kaempferi, shows potent antifungal activity. A key step in the total synthesis of 3 described (J. Am.…
Stereocontrolled Carbocyclic Construction: (-)-Mintlactone (Bates), (-)-Gleenol (Kobayashi), (-)-Vibralactone
C (Snider) Nigel S. Simpkins, now at the University of Birmingham, found (Chem. Commun. 2008, 5390. DOI: 10.1039/b810441g) that the prochiral cyclopropane amide 1 could be deprotonated to give, after…
Alkaloid Synthesis: Crispine A (Zhou), Cermizine C (Zhang), Tangutorine (Poupon), FR901483 (Kerr), Serratezomine A (Johnston)
Enantioselective hydrogenation of enamides is a well-established transformation. The corresponding reduction of enamines has been elusive. Qi-Lin Zhou of Nankai University designed (J. Am. Chem. Soc. 2009, 131, 1366. DOI:…
Ed myocardium of your spontaneously hypertensive rats (SHR), there was an
Ed myocardium with the spontaneously hypertensive rats (SHR), there was an increased activation of NHE1 and NHE1 inhibition lowered cardiac hypertrophy and interstitial fibrosis . Transgenic mice expressing activated NHE1…
Nce of LDL(-) in the LDL fraction of Ldlr-/-
Nce of LDL(-) inside the LDL fraction of Ldlr-/- mice was confirmed by physical chemical and antigenic characteristics. Macrophage viability. The MTT assay showed that cell viability was not impacted…
Selective Reactions of Alkenes
Fabio Doctorovich of the Universidad de Buenos Aires reported(J. Org. 201929-84-2 Chemscene Chem. 2008, 73, 5379DOI: 10.1021/jo800302v)that hydroxylamine in the presence of an Fe catalyst reduced alkenes such as 1,but…
Functionalization of C-H Bonds: The Baran Synthesis of Dihydroxyeudesmane
Arumugam Sudalai of the National Chemical Laboratory, Pune reported(Tetrahedron Lett. 2008, 49, 6401.DOI: 10.1016/j.tetlet.2008.08.071)a procedure for hydrocarbon iodination. With straight chain hydrocarbons, only secondary iodination was observed. 227454-58-2 site Chao-Jun…
Preparation of Benzene Derivatives: The Barrett Syntheses of Dehydroaltenuene B and 15G256b
Several new methods for the direct functionalization of Ar-H have appeared. PMID:24377291 Hisao Yoshida of Nagoya University observed (Chem. Comm. 2008, 4634. DOI: 10.1039/b811555a) that under irradiation, TiO2 in water…
Stereocontrolled Carbocyclic Construction: The Mulzer synthesis of (-)-Penifulvin
A Tanmaya Pathak of the Indian Institute of Technology, Kharagpur devised (J. Org. Price of 6-Chloro-3-fluoro-2-methoxypyridine Chem. NH2-PEG2-C2-Boc structure 2009, 74, 2710. DOI: 10.1021/jo802709q) a preparation of enantiomerically-pure oxygenated cyclopropanes…
Enantioselective Construction of Alkylated Stereogenic Centers
Carsten Bolm of RWTH Aachen developed (Angew. Chem. Int. Ed. 2008, 47, 8920 DOI: 10.1002/anie.200803709) an Ir catalyst that effected hydrogenation of trisubstituted enones such as 1 with high ee.…