The Grubbs Reaction in Organic Synthesis
Chemexpress Alkene metathesis (e.g. 1 + 2 -> 3) has been known at least since the 1950’s. Until Robert Grubbs of Caltech developed stable and versatile Ru catalysts for this transformation,…
New Methods for C-N Ring Construction
Chaozhong Li of the Shanghai Institute of Organic Chemistry demonstrated (Org. Lett. 2008, 10, 4037 DOI: 10.1021/ol801545a) facile and selective Cu-catalyzed β-lactam formation, converting 1 to 2. Paul Helquist of…
, respectively, didn’t reproducibly boost SS1P toxicity. The outcomes with
, respectively, did not reproducibly boost SS1P toxicity. The outcomes with INSR have been described previously (15). Knock down of Src slightly enhanced SS1P killing in each A431/H9 and KB…
Tions are described as follows: A, RNA processing and modification; B
Tions are described as follows: A, RNA processing and modification; B, Chromatin structure and dynamics; C, Energy production and conversion; D, Cell division and chromosome partitioning; E, Amino acid transport…
New Methods for Functional Group Conversion
Ilya M. Lyapkalo of the Academy of Sciences of the Czech Republic, Prague, showed(Synlett 2009, 558.DOI: 10.1055/s-0028-1087919)that a ketone 1 reacted with the inexpensive nonafluorobutanesulfonyl fluoridein the presence of a…
C-C Single Bond Construction
Several remarkable one-carbon homologations have recently appeared. André B. 1228281-54-6 Data Sheet Charette of the Université de Montréal reported (J. 2869955-58-6 Formula Org. Chem. 2008, 73, 8097. DOI: 10.1021/jo8014616) the…
Stereocontrolled C-O Ring Construction: The Fuwa/Sasaki Synthesis of Attenol
A Since five-membered ring ethers often do not show good selectivity on equilibration, single diastereomers are best formed under kinetic control. Aaron Aponick of the University of Florida demonstrated (Org.…
Part 1: Ultrasound-promoted palladium-catalyzed cross coupling reactions
Ultrasound-Promoted Heck Reaction in Room Temperature Ionic Liquids In 2001, Srinivasan and co-workers form National Chemical Laboratory, Pune, described the first Heck reaction performed in ionic liquids (IL) under ultrasound…
Part 2: Application of Ultrasound Irradiation in Carbohydrate Synthesis
Ultrasound energy: a powerful tool for carbohydrate synthesis Chang and co-workers from Utah State University, USA, have demonstrated that a large number of conventional reactions commonly employed for the synthesis…
Stereocontrolled Construction of C-N Rings: The Vanderwal Synthesis of Norfluorocurarine
Forrest E. Michael of the University of Washington described (Org. Lett. 5,6-Dichloropyridazin-3(2H)-one In stock Sodium triacetoxyborohydride In stock 2009, 11, 1147. DOI: 10.1021/ol9000087) the Pd-catalyzed aminative cyclization of 1 to…