Retigeranic acid (3), isolated from the Western Himalayas lichen Lobaria retigera, presents a variety of intriguing architectural challenges. Xiaoming Chen and Shao-Hua Wang of Lanzhou University devised a concise route…
Peyssonnoside A (3), isolated from the red alga Peyssonnelia sp., shows promising anti-microbial activity. PMID:24275718 Mingji Dai of Emory University assembled the tetracyclic core of 3 by the H-atom transfer…
Lissodendoric acid A (4), isolated from the marine sponge Lissodendoryx florida, reduced reactive oxygen species (ROS) in a Parkinson’s disease model. Fmoc-β-HoGlu(OtBu)-OH Chemscene Neil K. Garg of UCLA devised an…
Albolic acid (3) and ceroplastol II, the corresponding primary alcohol, are sesterterpenoids isolated from the wax secretion of Ceroplastes albolineatus, a scale insect. Chuang-Chuang Li of the Southern University of…
Napelline (3) was isolated from Aconitum kusnezoffii, a widely-cultivated herbaceous perennial that, despite its toxicity, has long been used in traditional medicine. Xiangbo Zhao and Dawei Ma of SIOC assembled…
Yan Qi and Yongjun Liu of the Qingdao University of Science and Technology demonstrated that the assembly of the tertiary alcohol 3 by the Barbier coupling of cyclohexanone 1 with…
Qingtao Meng and Zhiqiang Zhang of the University of Science and Technology Liaoning and Yu-Peng He of the Dalian University of Technology used the amide of 1 to direct acetoxylation,…
Grubbs metathesis has proven to be a powerful tool for the rapid construction of complex heterocycles. Shengming Ma of the the Shanghai Institute of Organic Chemistry reports (J. Org. Methyl…
Following the Wenkert approach, Jun Huang and Zhen Yang of Peking University prepared the alkylated aldehyde 2 by conversion of the aldehyde 1 to the silyl enol ether, followed by…
Piperarborenine B (3), isolated from the stem of Piper arborescens, shows significant and selective antineoplastic activity. 2-(4,4-Difluorocyclohexyl)acetic acid site Andrey P. Antonchick of Nottingham Trent University constructed the cyclobutane core…
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