The nigellamine alkaloids, represented by (-)-nigellamine (3), dolabellane diterpenes isolated from black cumin, apparently have lipid metabolism promoting activity. Joseph M. Ready of UT Southwestern Medical Center has described (J.…
Erythronolide A (4), with its array of ten stereogenic centers, is the parent of several classic antibiotics, including erythromycin. The key step in the total synthesis of 4 recently reported…
Gelsemine 3 has no particular biological activity that recommends it, but its challenging architecture has been a motivation to a generation of organic synthesis chemists. Larry E. Overman of the…
The galbulimima alkaloids have intriguing physiological activity, but the absolute configuration of glabulimima alkaloid 13 (3) had not been assigned. Mohammad Movassaghi of the Massachusetts Institute of Technology has developed…
The loss of mental function associated with aging is thought to be due at least in part to the degradation of neurite connections between neurons. Natural products such as (-)-littoralisone…
The history of reserpine (3), isolated from the Indian shrub Rauwolfia serpentina, is storied. The anxiolytic activity of reserpine, the first tranquilizer, pointed the way to the development by Hoffmann-LaRoche…
He number of second generation people inside a brood decreased with rising concentration of pyroproxyfen (Fig. 7E) suggesting that pyriproxyfen decreased the number of oocytes recruited for maturation or elevated…
Hat YGTSS tic severity was higher for youth withFIG. 1. Breakdown of Diagnostic Interview Schedule for Children (DISC)generated tic disorder diagnosis for youth and parent respondents.UTILITY Of the DISC FOR…
Applications to natural product synthesis probe the limits of any synthetic method, as situations arise that would never have been considered in the course of first developing the method. PMID:35567400…
Although oxidation and reduction are common organic synthesis transformations, there is always room for improvement. The ideal reaction might use a solid, easily-measured reagent, a minimal amount of solvent, need…
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