A 144-member library of furocoumarins via three-component reaction of 4-hydroxycoumarins, isocyanides and arylaldehydes was prepared by Jie Wu from VivoQuest Inc., NY (Chem. Lett. 2006, 35, 118. (4-Chlorophenyl)(2-nitrophenyl)sulfane web DOI:…
Enzymes have many applications in organic synthesis. One of the most common is the resolution of a secondary alcohol. A shortcoming of this approach is that the separation of the…
Jie Yan and co-workers from Zhejiang University of Technology, China, have reported on Suzuki-type couplings in water without the use of catalyst and base (Eur. J. PMID:23558135 Org. P(t-Bu)3 Pd…
Sarah Mossé and Alexandre Alexakis from the University of Geneva have reinvestigated asymmetric aldol (a), Mannich (b) and Diels-Alder reactions (c) applying organocatalysis under microwave conditions (Org. PMID:23912708 Lett. BuyRuPhos…
The Diels-Alder reaction is a powerful tool for the construction of substituted cyclohexenes. Erik J. Formula of 1234616-36-4 Sorenson of Princeton University has developed (J. Am. 2-(2-Bromoethyl)oxirane Formula Chem. Soc.…
Yong-Gui Zhou of the Dalian Institute of Chemical Physics (Angew. Chem. PMID:28038441 Int. Ed. 2006, 45, 2260. Pyrimidine-2-carbaldehyde web DOI: 10.1002/anie.200503073)and Manfred T. Reetz of the Max-Planck-Institut, Mülheim (Chem. Commun.…
Carbon-carbon bond formation is central to organic synthesis. In the ideal, a homologation method will start with a common functional group, and proceed under mild conditions using non-toxic reagents. These…
Classsically, stoichiometric oxidants have been used to convert alcohols into aldehydes and ketones. Acetosyringone manufacturer A practical alternative is to use air oxidation, with a transition metal catalyst. Usually, a…
Groups The DDQ cleavage of a benzyl ether is a classic transformation, yet it has not always been reliable. Kazunobu Toshima of Keio University has recently (Tetrahedron Lett. 2005, 46,…
Powerful transition metal-catalyzed methods for the conversion of prochiral alkenes and alkynes to carbocyclic rings have been developed over the past several years. Three recent reports are representative. P. Andrew…
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