Indolizidine 209D (3), isolated from the neotropical "poison dart" frog, inhibits neuromuscular transmission. Hanyue Qiu, Ling He and Min Zhang of Chongqing University rearranged the cyclopropanol 1, prepared from the…
Ai-Lan Lee of Heriot-Watt University developed a protocol for the decarboxylation of the carboxylic acid 1 to the hydride 2 (Org. Lett. 2022, 24, 686. DOI: 10.1021/acs.orglett.1c04079). Joseph R. Clark…
Histology of proximal tibia showed important decreases in MS/BS, MAR and BFR/BS in the OVX rats compared with the sham, plus the CFE group totally maintained these parameters for the…
Lbeit to a lesser extent than with phenformin, and DHAP and glyceraldehyde3phosphate are slightly decreased. Neither biguanide has an impact around the earliest glycolytic intermediates that are elevated during transformation…
Jin-Na Song of Jilin University and Yongquan Ning of Northeast Normal University assembled the furan 3 by combining the diazoalkane derived in situ from the tosylhydrazone 2 with the β-keto…
Pher G. Andersson of Stockholm University showed that a Z/E mixture of the enone 1 could be hydrogenated to 2 in high ee (Nature Commun. 2022, 13, 361. DOI: 10.1038/s41467-022-28003-6).…
Stefan Schulz of the Technische Universität Braunschweig updated the classic intramolecular Diels-Alder cycloaddition of the triene 1 to the ketone 2, readily convertible to δ-cadinol (3), by preparing 1 via…
Liang-Nian He of Nankai University and Chao-Jun Li of McGill University converted the hydrazone of carvone 1 to the triene 2 (JACS Au 2022, 2, 1929. DOI: 10.1021/jacsau.2c00320). Mathias Schelwies…
Xufeng Lin of Zhejiang University used an enantiomerically-pure bis iodide to mediate the oxidative cyclization of the prochiral amine 1 to the lactam 2 (Tetrahedron Lett. 2022, 109, 154157. DOI:…
Efficient new methods for oxidation are always welcome. The Dess-Martin periodinane has become the workhorse for alcohol to aldehyde or ketone conversion in organic research labs around the world. 5-Azaspirooctane-6,8-dione…
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