The Zakarian Synthesis of (+)-Pinnatoxin A
Chemexpress (+)-Pinnatoxin A (3), isolated from the shellfish Pinna muricata, is thought to be a calcium channel activator. A key transformation in the synthesis of 3 reported (J. Am. Chem. Soc.…
N and theCharacterization in the mAbThe cross reactivity on the mAb
N and theCharacterization of your mAbThe cross reactivity in the mAb 2G12E1 was tested using artesunate, dihydroartemisinin, artemisinin along with other important antimalarial drugs in icELISA (Table 1). The cross…
Ug/ml. Following choice, steady clones were isolated by limiting dilution.
Ug/ml. Following selection, steady clones have been isolated by limiting dilution. Knockdown was monitored by operating complete cell lysates and/or spent media on gels and probing with versican antibodies as…
The Johnson Synthesis of Zaragozic Acid C
The zaragozic acids, exemplified by Zaragozic Acid C (3), are picomolar inhibitors of cholesterol biosynthesis. Jeffrey S. PMID:26446225 2126818-91-3 custom synthesis Johnson of the University of North Carolina developed (J.…
The Paquette Synthesis of Fomannosin
The compact sesquiterpene (+)-fomannosin (3), isolated from the pathogenic fungus Fomes annonsus, presents an interesting set of challenges for the organic synthesis chemist, ranging from the strained cyclobutene to the…
Protection of Organic Functional Groups
Several noteworthy new developments in the protection and deprotection of alcohols have been reported. Price of 2-Aminoacetamide Andrea Biffis of the Università di Padova has developed (Adv. Synth. Catal. 2007,…
Oxidative Heck Arylations
A recent publication by Mats Larhed and co-workers from Uppsala University (J. Org. 5-Chloro-4-methylpyridin-3-amine Purity Chem. 2004, 69, 5212.DOI: 10.1021/jo049434t)describes dioxygen-promoted regioselective oxidativeHeck arylations of electron-rich olefins with arylboronic acids.…
Alkene and Alkyne Metathesis: Phaseolinic Acid (Selvakumar), Methyl 7-Dihydro-trioxacarcinoside B (Koert), Arglabin (Reiser) and Amphidinolide V (Fürstner)
As N. Azido-PEG8-acid Purity Selvakumar of Dr. Reddy’s Laboratories, Ltd., Hyderabad approached (Tetrahedron Lett. 2007, 48, 2021.DOI: 10.1016/j.tetlet.2007.01.053)the synthesis of phaseolinic acid (6), there was some concern about the projected…
Reactions of Alkenes
One of the most powerful of alkene transformations is enantioselectiveepoxidation. Tsutomu Katsuki of Kyushu University has developed (Angew. Chem. Int. 2,5-Dimethoxy-4-formylphenylboronic acid Order Ed. 2007, 46, 4559.DOI: 10.1002/anie.200700949)a Ti catalyst…
C-H Functionalization to Form C-O, C-N, and C-C Bonds
A classic example of C-H functionalization is the familiarNBSbromination of a benzylic site. Recent updates of this approach allow for direct alkoxylation(J. Am. Chem. Soc. 2008, 130, 7824DOI: 10.1021/ja8031218)and net…