Product Name :
Noxa Recombinant Rabbit Monoclonal Antibody [JA30-03]
Predicted band size :
Observed band size :
Synonyms:
Adult T cell leukemia derived PMA responsive antibody APR antibody APR_HUMAN antibody ATL-derived antibody Immediate early response protein APR antibody Immediate-early-response protein APR antibody NOXA antibody Phorbol 12 myristate 13 acetate induced protein 1 antibody Phorbol-12-myristate-13-acetate-induced protein 1 antibody PMA induced protein 1 antibody 展开
Function :
Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human Noxa aa 5-54 / 54.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JA30-03
RRID:
AB_3070485
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.(3-Chloronaphthalen-2-yl)boronic acid manufacturer
Storage buffer solution:
1*TBS (pH7.439579-12-1 structure 4), 0.PMID:33387155 05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 6 kDa
Positive control :
Human spleen tissue, human liver tissue, Jurkat, mouse lung tissue, rat lung tissue.