C-H Functionalization: The Zhu Synthesis of β-Cuparenone
Chemexpress Soon Hyeok Hong of KAIST devised the photochemically-promoted coupling of the acid chloride 2 with the hydrocarbon 1, leading to the ketone 3 as a mixture of diastereomers (Nature Commun.…
NtPLOS A single | www.plosone.orgLipoprotein Profiles in Mice with Humanized Livershuman
NtPLOS 1 | www.plosone.orgLipoprotein Profiles in Mice with Humanized Livershuman FGF19 (PeproTech, Catalog # 10032) was reconstituted in 0.9 saline with 0.1 BSA and three humanized and 3 manage FRGN…
Acterial virulence around the Arabidopsis ecotype Columbia or the tomato `Moneymaker
Acterial virulence on the Arabidopsis ecotype Columbia or the tomato `Moneymaker’ cultivar (Wei et al., 2007). So that you can identify much more robust diseaserelated phenotypes, we generated transgenic dexamethasone…
Carbon-Carbon Bond Formation: The Kalesse Synthesis of Illisimonin A
Biplap Maji of the Indian Institute of Science Education and Research Kolkata prepared the α-hydroxy acid 3 by combining the primary alcohol 1 with ethylene glycol 2 (Angew. Chem. Formula…
Enantioselective Construction of Single Stereogenic Centers
Single enantiomer synthesis is of increasing importance in pharmaceutical production. It is essential that practical and scalable procedures be developed for controlling the absolute configuration of new stereogenic centers as…
Reactions of Alkenes: The Chida Synthesis of Paclitaxel (Taxol®)
Alison E. Buy103128-76-3 Wendlandt of MIT devised a protocol for the contrathermodynamic isomerization of the alkene 1 to the alkene 2 (J. Am. Chem. Soc. 2022, 144, 145. DOI: 10.1021/jacs.1c12043).…
Reactions of Alkenes: The Tanino Synthesis of 2-Isocyanoallopupukeanane
Yasunori Toda and Hiroyuki Suga of Shinshu University achieved high regioselectivity in the conversion of the epoxide derived from 1 to the oxazoline 2 (Chem. Commun. 3-(4-Fluorophenoxy)azetidine Order 2022, 58,…
Diels-Alder Cycloaddition: Rameswaralide (Romo), Lucidumone (de la Torre), Anthracimycin (Qian/Tong), Alstonlarsine A (Ferjancic/Bihelovic), Ophiorrine A (Vincent), Daphgraciline (Sun/Li)
Rameswaralide (4), isolated from the soft coral Sinularia dissecta, showed modest cytotoxicity. 2411793-14-9 supplier In the course of a synthesis of 4, Daniel Romo of Baylor University showed that with…
Alkaloid Synthesis: Indolizidine 209D (Qiu/He/Zhang), Kopsone (Yokoshima), Quinocarcin (Zheng/Huang), Daphnillonin B (Li), Daphnezomine B (Zhai), Vilmoraconitine (Liu/Qin)
Indolizidine 209D (3), isolated from the neotropical "poison dart" frog, inhibits neuromuscular transmission. Hanyue Qiu, Ling He and Min Zhang of Chongqing University rearranged the cyclopropanol 1, prepared from the…
Reduction: The Odagi/Nagasawa Synthesis of Cepharatine A
Ai-Lan Lee of Heriot-Watt University developed a protocol for the decarboxylation of the carboxylic acid 1 to the hydride 2 (Org. Lett. 2022, 24, 686. DOI: 10.1021/acs.orglett.1c04079). Joseph R. Clark…