Kamebanin (3), isolated from the Japanese flowering plant Isodon kameba Okuyama (Isodon umbrosus), showed cytotoxic and antibiotic activity. Takahiro Suzuki and Keiji Tanino of Hokkaido University devised a route to…
Cyclopamine (4), a teratogenic alkaloid isolated from the California corn lily Veratrum californicum, has been shown to disrupt the hedgehog signalling pathway. Phil S. Baran of Scripps/La Jolla envisioned a…
Trachinol (3), isolated fifty years ago from Sideritis canariensis Ait., a shrub of the Canary Islands, has an intriguing pentacyclic structure. Chun-An Fan of Lanzhou University devised an elegant preparation…
By C MunozPinedoReovirus induces ER anxiety JS Carew et alsubstantial accrual of ubiquitinconjugated proteins and induced ER stressmediated apoptosis in each in vitro and in vivo models of pancreatic cancer.146…
12). The presence of a higher amount of cAMP in the subcortical compartment appears to be essential for PKAmediated regulation of CFTR activity as remedy with latrunculin B was sufficient…
Xiaoxia Ye of Wenzhou Medical University and Jun Jiang of Wenzhou University used the barium salt of proline to direct the aldol reaction of the prochiral cyclobutanone 1 with the…
Yiyun Chen of the Shanghai Institute of Organic Chemistry used the benziodoxole reagents 2 and 3 to convert the activated oxime 1 to the alkyne 4 (Org. Lett. 2022, 24,…
Kwihwan Park, Tsuyoshi Yamada, and Hironao Sajiki of Gifu Pharmaceutical University devised conditions for the exchange of the allylic alcohol 1 with D2O, to give the trideuterated allylic alcohol 2…
Burkhard König of University Regensburg observed significant diastereoselectivity in the conversion of the ketone 1 to the aldehyde 2 (Angew. Chem. Int. PMID:30125989 Ed. 2022, 61, e202211578. DOI: 10.1002/anie.202211578). John…
Acyclic stereoarrays are important both in themselves and as precursors to enantiomerically-defined ring systems. Although the aldol condensation has for many years been a workhorse for acyclic stereoselection, there are…
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