E (FITC), anti B7-H1 mAb (eBioscience, Minneapolis, MN), and anti-mouse immunoglobulin conjugated with FITC (Dako Denmark A/S, Glostrup, Denmark). Detection of surface CD80 and CD86 was carried out employing unconjugated…
Ges in eCB receptors, enzymes or transporters. Anti-depressant drugs had distinct effects in other brain regions. Within the frontal cortex, chronic administration of NAC elevated AEA levels, whilst 2-AG levels…
Amos B. Smith III of the University of Pennsylvania found (Synlett 2009, 3131. DOI: 10.1055/s-0029-1218352) that the advanced SAMP intermediate 1 could be deprotected to 2 without racemization under mild…
α-Agorafuran Valery V. Fokin of Scripps/La Jolla extended (J. Am. Chem. Soc. 1279894-35-7 Purity 2010, 132, 2510. DOI: 10.1021/ja910187s) enantioselective Rh-mediated intermolecular cyclopropanation to α-olefins such as 1. Takahiro Nishimura…
Renat Kadyrov of Evonik Degussa and Magnus Rueping of RWTH Aachen developed (Angew. Chem. Int. Ed. 2009, 49, 7556. DOI: 10.1002/anie.200902835) an effective catalyst for the enantioselective hydrogenation of an…
Arene diazonium salts are effective precursors for the Heck reaction. Sandro Cacchi of the Università degli Studi “La Sapienza”, Roma, observed(Synlett 2009, 1277.DOI: 10.1055/s-0028-1088132)that the diazonium salt generated in situ…
Jianbo Wang of Peking University described (Angew. Chem. Int. Ed. 2010, 49, 2028. DOI: 10.1002/anie.200906699) the Au-promoted bromination of a benzene derivative such as 1 with N-bromosuccinimide. In a one-pot…
There are two major impediments to the scaling up of alkene metathesis, reducing the amount of the expensive Ru catalyst required, and minimizing residual Ru in the product. Robert H.…
(-)-Adaline (Yu), (-)-Securinine (Bayón/Figueredo), Alkaloid 223A (Aubé), (-)-Huperzine A (Fukuyama) The recent development of practical methods for the asymmetric preparation of amines has enabled creative approaches to alkaloid construction. Cyclopropylmethyl…
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