Benzyl esters are easily deprotected by hydrogenolysis. It is often observed, however, as exemplified by the conversion of 1 to 2 reported (Adv. Synth. Catal. 6-Bromo-4(1H)-cinnolinone Chemical name 2008, 350,…
Complex natural products and even some complex pharmaceuticals contain arrays of stereogenic centers. Sometimes, the desired array is readily available from a natural product, but usually, such arrays of multiple…
Jaiwook Park of Pohang University of Science and Technology has developed (Org. Lett. 2007, 9, 3417.DOI: 10.1021/ol701456w)a procedure for the preparation of Pd-impregnated magnetic Fe nanoparticles. This effective hydrogenation catalyst…
The construction of carbon-carbon bonds is fundamental to organic synthesis. PMID:23880095 Recently, three new methods have been reported, each of which has substantial potential for the synthesis of highly functionalized…
The enantioselectivity of alkene reduction usually depends on the geometric purity of the alkene. Bruce H. Lipshutz of the University of California, Santa Barbara used (Org. Lett. 2007, 9, 4713.DOI:…
Armando Córdova of Stockholm University has found (Tetrahedron Lett. 2008, 49, 4209. DOI: 10.1016/j.tetlet.2008.04.162)that the organocatalyst 3a effected enantioselective conjugate addition of bromonitromethane 2 to the α,β-unsaturated aldehyde 1, to…
Often, 6,6-spiroketals such as Spirofungin A (3) have a strong anomeric bias. Spirofungin A does not, as the epimer favored by double anomeric stabilization suffers from destabilizing steric interactions. Tetrabutylammonium…
Lograft is shown. (D.) CD8+CD122+PD-1+ Tregs isolated from na e B6 mice mainly expressed FasL prior to their adoptive transfer, as determined by flow analyses. One particular of two separate…
The polyene macrolide RK-397 (3), isolated from soil bacteria, has antifungal, antibacterial and anti-tumor activity. Tarek Sammakia of the University of Colorado has described (Angew. 1-Acetoxy-1,2-benziodoxol-3-(1H)-one site Chem. PMID:23546012 Int.…
The pentacyclic alkaloid (+)-lyconadin A (3), isolated from the club moss Lycopodium complanatum, showed modest in vitro cytotoxicity. A key step in the first reported (J. PMID:23805407 Am. Chem. Soc.…
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