Alkene metathesis has been extended to increasingly complex starting materials and products. Nitriles are good donors to coordinatively-unsaturated transition metal centers, so tend to inhibit the reaction. PMID:35345980 Ren He…
Several new developments in enantioselective C-O ring construction have been applied in the syntheses of natural products. Buy3-(Hydroxymethyl)pyrrolidin-2-one To achieve control, the oxygenated quaternary center of dysiherbaine (9) must be…
Several new routes to furans and to pyrroles have recently been put forward. Inspired by the Achmatowicz ring expansion, Patrick J. Walsh of the University of Pennsylvania developed (J. Am.…
Jeffrey C. Pelletier of Wyeth Research, Collegeville, PA has developed (Tetrahedron Lett. 2007, 48, 7745. DOI: 10.1016/j.tetlet.2007.09.034)a easy work-up Mitsunobu procedure for the conversion of a primary alcohol such as…
Usually, only a single enantiomer of a pharmaceutical is the useful drug. Often, the synthesis of the single enantiomer depends on the ability to form C-O or C-N bonds with…
Although natural amino acids are readily available, there is a continuing need for unnatural amino acids. Jon C. Antilla of the University of South Florida has described (J. Am. Chem.…
There continue to be new developments in transition metal- and lanthanide-mediated construction of carbocycles. Although a great deal has been published on the asymmetric cyclopropanation of styrene, relatively little had…
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