The guanacastepenes, of which guanacastepene E (3) is representative, initially elicited excitement because of their activity against drug resistant bacterial strains. Although the systemic toxicity of the guanacastepenes has cooled…
The symmetrical macrodiolide (+)-SCH 351448 (4) is the only known selective activator of transcription from the low density lipoprotein receptor. The highly convergent synthesis of 4 from 1 and 2…
Larry E. Overman of the University of California, Irvine has recently (Angew. Chem. Int. PMID:25959043 2,4-Bis(trifluoromethyl)benzaldehyde supplier Ed. 2006, 45, 2912. DOI: 10.1002/anie.200600417)described the first total synthesis of the antibiotic…
(+)-Rishirilide (4), an inhibitor of α2-macroglobulin, a tetrameric serum glycoprotein that is an irreversible protease inhibitor, has a deceptively simple structure. Thomas R. R. Pettus of the University of California…
Vigulariol (3), isolated from the octocoral Vigularia juncea (Pallas), is active against human lung adenocarcinoma cells (IC50 = 18 nM). A key step in the synthesis of 3 reported (Angew.…
Albert Padwa of Emory University has developed (Org. PMID:23664186 Fmoc-Ala-OH supplier Lett. 2006, 8, 3275. DOI: 10.1021/ol061137i) a productive approach to fused indole alkaloids such as aspidophytine (3), based on…
The report last year by scientists at Merck of an antibiotic, platensimycin3, with a novel mechanism of action has led to much effort toward the total synthesis of this degraded…
The total synthesis of steroids such as (+)-digitoxigenin (3) has been studied for more than sixty years, yet it has never been thought that such studies would lead to a…
Historically, there have been three methods for assembling enantiomerically-pure carbocycles: cyclization of an enantiomerically-pure starting material, enantioselective cyclization of a prochiral substrate, and enantioselective transformation of a prochiral cyclic starting…
Jin-Quan Yu of Cambridge University reports (Org. PMID:35567400 Lett. 2003, 5, 4665. DOI: 10.1021/ol0358509) that Pd nanoparticles catalyze the hydrogenolysis of benzylic epoxides. The reaction proceeds with inversion of absolute…
Chemexpress