Rare Sugars Are Now Readily Available Chiral Pool Starting Materials
Chemexpress Many of the five- and six-carbon sugars, although well known, are rare, and too expensive to be used as chiral pool starting materials. David MacMillan of Caltech in an elegant…
Enantioselective Synthesis of Alcohols and Amines: The Lin/Liu Route to Haliclamide
Benjamin List of the Max-Planck-Institut für Kohlenforschung used a confined imidodiphosphorimidate to catalyze the cyclization of the unsaturated acid 1 to the lactone 2 (J. Am. Chem. Soc. 2023, 145,…
Functional Group Interconversion: The Nagasawa/Iwabuchi Synthesis of Rumphellclovane E
Christopher B. 2-Aminoacetamide uses Kelly of Janssen Discovery Process, Osvaldo Gutierrez of Texas A&M and Mark D. Levin of the University of Chicago used the N-acyloxy N-alkoxy amide 2 to…
C-O Ring Construction: The Menche Synthesis of Pentamycin
Guisheng Zhang and Zhiguo Zhang of Henan Normal University rearranged the activated cyclopropane 1 with catalytic 2, leading to the dihydrofuran 3 (J. Org. PMID:23800738 Chem. 2023, 88, 1003. DOI:…
The Suzuki/Tanino Synthesis of Kamebanin
Kamebanin (3), isolated from the Japanese flowering plant Isodon kameba Okuyama (Isodon umbrosus), showed cytotoxic and antibiotic activity. Takahiro Suzuki and Keiji Tanino of Hokkaido University devised a route to…
The Baran Synthesis of Cyclopamine
Cyclopamine (4), a teratogenic alkaloid isolated from the California corn lily Veratrum californicum, has been shown to disrupt the hedgehog signalling pathway. Phil S. Baran of Scripps/La Jolla envisioned a…
The Fan Synthesis of Trachinol
Trachinol (3), isolated fifty years ago from Sideritis canariensis Ait., a shrub of the Canary Islands, has an intriguing pentacyclic structure. Chun-An Fan of Lanzhou University devised an elegant preparation…
By C MunozPinedoReovirus induces ER anxiety JS Carew et alsubstantial accrual
By C MunozPinedoReovirus induces ER anxiety JS Carew et alsubstantial accrual of ubiquitinconjugated proteins and induced ER stressmediated apoptosis in each in vitro and in vivo models of pancreatic cancer.146…
12). The presence of a high degree of cAMP within the subcortical
12). The presence of a higher amount of cAMP in the subcortical compartment appears to be essential for PKAmediated regulation of CFTR activity as remedy with latrunculin B was sufficient…
Organocatalyzed C-C Ring Construction: The Takao Synthesis of Puraquinonic Acid
Xiaoxia Ye of Wenzhou Medical University and Jun Jiang of Wenzhou University used the barium salt of proline to direct the aldol reaction of the prochiral cyclobutanone 1 with the…