Usually, aryl-aryl bonds are formed by the coupling of two functionalized aromatic carbons. Formula of Mesityl-λ3-iodanediyl diacetate Having both of the aromatic carbons functionalized is not always necessary. It is…
Alkenes are among the least expensive of organic functional groups. They are easily incorporated into a growing molecule, and are stable to many of the reagents that transform other functionality.…
Intramolecular carbene insertion (e.g. 1 -> 3) has long been a useful method for ring construction. Masahisa Nakada of Waseda University in Tokyo now reports (J. Am. Chem. Soc. Buy5-Methoxyquinazolin-4(3H)-one…
The tetracyclic alkaloid quinine 1 and the diastereomeric alkaloid quinidine 2 share a storied history. Eric Jacobsen of Harvard recently completed (J. PMID:25027343 Buy2-Chloro-1H-indole Am. Chem. Soc. 2004, 126, 706.DOI:…
Alkene and alkyne metathesis, well-developed synthetic methods, are now often employed in natural product synthesis. The total syntheses outlined here are noteworthy for their creative application of these reactions. Buy7-Amino-4-bromoisoindolin-1-one…
Diimide (H-N=N-H) is an effective reagent for reducing alkenes. Yasushi Imada and Takeshi Naota of Osaka University have devised (J. Am. Chem. Soc. 2005, 127, 14544. DOI: 10.1021/ja053976q)a flavin-catalyzed protocol…
N-heterocyclic salts are air-stable crystalline solids that can be stored with no special precautions and are the precursors of N-Heterocyclic Carbenes (NHCs), which are produced upon treatment with an appropriate…
Alkene and alkyne metathesis have, in a relatively short time, become important tools for organic synthesis. Carlos Saá of the Universidad de Santiago de Compostela has developed (J. Am. PMID:23927631…
One of the simplest ways to construct alkylated ternary centers is enantioselective catalytic hydrogenation. Xumu Zhang of Pennsylvania State University has devised (Angew. Chem. Int. Ed. 2005, 44, 4933. 1803603-34-0…
Nitrogen heterocycles are the basis of many essential pharmaceuticals, and of many physiologically-active natural products. There is a continuing interest in the development of new methods for the construction of…
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