Preparation of Benzene Derivatives
Chemexpress Two of the most common methods for homologating an aryl halide are the Heck reaction (1 -> 3) and the Suzuki reaction (4 -> 6). Shriniwas D. Samant of the…
Microwave-Assisted Suzuki Couplings with Simultaneous Cooling
Suzuki couplings using a microencapsulated palladium catalyst (Pd EnCat) under microwave heating were investigated by the group of Steven V. PMID:34856019 Ley at the University of Cambridge (Chem. 1450752-97-2 Purity…
Asymmetric Mannich Reaction
Carsten Bolm and Belén Rodríguez from the University of Aachen investigated thermal effects in the (S)-proline-catalyzed Mannich reaction (J. Org. Chem. 2006, 71, 2888. (R)-2-Methylazetidine hydrochloride structure DOI: 10.1021/jo060064d). By…
Phosphine Gold(I)-Catalyzed Hydroamination of Alkenes
Chi-Ming Che and co-workers from the University of Hong Kong have reported on the intra- and intermolecular hydroamination of unactivated alkenes (Org. Lett. 2006, 8, ASAP. DOI: 10.1021/ol060719x). In a…
Synthesis of 7-Azaindoles
Hartmut Schirok from Bayer HealthCare, Germany, has reported on a short and flexible synthesis of 1,3-substituted 7-azaindoles 2 starting from oxiranes 1 (J. PMID:23724934 Org. Chem. 2006, 71, 5538.DOI: 10.1021/jo060512h).…
Ring Closing Metathesis for Guaianolide Synthesis
Oliver Reiser and his group from the University of Regensburg, Germany have reported on the ring-closing metathesis (RCM) of a sterically demanding substrate in the context of the total synthesis…
Synthesis of Furocoumarin Libraries
A 144-member library of furocoumarins via three-component reaction of 4-hydroxycoumarins, isocyanides and arylaldehydes was prepared by Jie Wu from VivoQuest Inc., NY (Chem. Lett. 2006, 35, 118. (4-Chlorophenyl)(2-nitrophenyl)sulfane web DOI:…
Single-Step Synthesis of Pyrimidine Derivatives
Mohammad Movassaghi and Matthew D. Hill from MIT have developed a protocol for the synthesis of quinazolines 1 via electrophilic activiation of secondary amides utilizing 2-chloropyridine (2-ClPyr) in combination with…
Enzymes in Organic Synthesis
Enzymes have many applications in organic synthesis. One of the most common is the resolution of a secondary alcohol. A shortcoming of this approach is that the separation of the…
Organocatalyzed Asymmetric Reactions
Sarah Mossé and Alexandre Alexakis from the University of Geneva have reinvestigated asymmetric aldol (a), Mannich (b) and Diels-Alder reactions (c) applying organocatalysis under microwave conditions (Org. PMID:23912708 Lett. BuyRuPhos…