Inhibitors Salinosporamide A, Omuralide and Lactacystin The structurally-related γ-lactams salinosporamide A (1), omuralide (2) and lactacystin (3), of bacterial origin, inhibit proteasome activity, and so are of interest as lead…
While alkyne metathesis is not going to displace alkene metathesis as a synthetic method, it is a complementary approach that can offer advantages. Catalysts for alkyne metathesis are still under…
The enantioselective oxygenation procedures, epoxidation and dihydroxylation, developed by Barry Sharpless have dominated single-enantiomer organic synthesis. Recently, several additional methods for enantioselective oxidation have been developed, based on the α-functionalization…
Arrays of Stereogenic Centers Single enantiomer synthesis is of increasing importance in pharmaceutical production. It is essential that practical and scalable procedures be developed for controlling the absolute configuration of…
Although many methods have been developed for enantioselective carbon-carbon construction, not all of these are robust and scalable. A promising recent addition has been the development of protocols for the…
Benzyl ethers are among the most commonly used protecting groups for alcohols. PMID:23554582 Usually, these are prepared using an excess of NaH and benzyl bromide. Buy1-(Aminomethyl)cyclopentanol Okan Sirkecioglu of Istanbul…
The push toward enantiomerically-purecarbocyclic intermediates has led to the development of new methods for the enantiodifferentiation of inexpensive prochiral cyclic starting materials. For instance, Robert H. Morris of the University…
In the last few years, chiral sulfoxides have become important targets in organic synthesis, and their chemistry has recently been reviewed (Org. Chem. Highlights 2004, December 24. Link). An increasing…
The asymmetric conjugate addition is regarded as one of the most powerful tools for the selective formation of chiral C-C or C-X bonds. Particular cases of this methodology are the…
Weaker and longer than covalent linkages, hypervalent bonds are the result of a linear three-center, four-electron (3c-4e) electronic distribution (hypervalent model). PMID:23927631 Hypervalent iodine reagents are useful synthetic tools due…
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