Reduction: The Dai Synthesis of Massarinolin A
Chemexpress Xiaobei Chen,Yanwei Hu and Shilei Zhang of Soochow University showed that the inexpensive calcium hydride could be used to reduce the aryl halide 1 to the arene 2 (Org. Chem.…
Alkylated Stereogenic Centers: The Ogawa Synthesis of Heliannuol E
Bruce H. Lipshutz of the University of California, Santa Barbara developed surfactants that allowed the aqueous enzymatic reduction of the enone 1 to the ketone 2 (Chem. Commun. 2021, 57,…
Best Methods for C-C Bond Formation: Part Two of Three
Carbon-carbon bond formation is fundamental to all of organic chemistry. PMID:28440459 The emphasis this week is on recently-developed useful transformations that are easily scalable. Notably, these transformations telescope two or…
Rom 3 unique donors. (, p 0.05; , p 0.01).ing resulted within a considerable
Rom 3 distinct donors. (, p 0.05; , p 0.01).ing resulted in a substantial enhance in STAT1 protein levels in these cells (Fig. 3F). Paralleling STAT1 protein levels, levels of…
Bbreviated as (CP/C), revealed the differential expression of 329 genes involving
Bbreviated as (CP/C), revealed the differential expression of 329 genes amongst the two biofilms (see Tables two, S4 and S5). Comparison of gene expression upon selfcolonization (CC/C experiment) and upon…
Alkaloid Synthesis: Impatien A (Watson), cis-195J (Schneider), Galanthamine (Zhao), Stemoamide (Tang), Lythranidine (Sherburn), Aspidospermine (Liu)
Impatien A (3) was isolated from the Corydalis impatien, a flower of south China that is an important component in traditional Chinese medicine. Cyclopropanecarbaldehyde Order Donald A. Watson of the…
C-O Ring Construction: Burseran (Tanaka), Hyperione A (Dai), Spirotenuipesine A (Imagawa), Stachyodin A (Ito), Alstilobanine C Zhu), Biselide A (Britton)
The sap from the elephant tree of northern Mexico, Bursera microphylla, was used locally as a cure-all for diseases, particularly those affecting the skin. Hiroshi Tanaka of the Tokyo University…
Heteroaromatics: The Cho Synthesis of Decursivine
Marie-Isabelle Lannou and Geoffroy Sorin of the Université de Paris used Ag2O to cyclize the alkyne 1 to the furan 2 (Chem. Commun. 2022, 58, 1374. DOI: 10.1039/D1CC06379K). Rishikesh Narayan…
C-O Ring Construction: Triciadolide C (Wang), Nesteretal A (Ito), Toxicodenane (Han), Dehydro-exo-Brevicomin (Kanomata), Diocollettines A (Houk/Smith), Heliannuol K (Green)
The maleic anhydride derivative triciadolide C (3) was isolated from the aquatic hyphomycete Tricladium castaneicola. PMID:23460641 Shaozhong Wang of Nanjing University developed a general route to such anhydrides, exemplified by…
C-N Ring Construction: The Karimov Synthesis of a Nuphar Alkaloid
Weidi Cao and Xiaoming Feng of Sichuan University achieved high enantioselectivity in the ring expansion of the racemic aziridine with the isonitrile 2 to give the azetidine 3 (Org. Lett.…