Heteroaromatics: The Wei/Zu Synthesis of Gilbertine
Chemexpress Jin-Na Song of Jilin University and Yongquan Ning of Northeast Normal University assembled the furan 3 by combining the diazoalkane derived in situ from the tosylhydrazone 2 with the β-keto…
Enantioselective Construction of Alkylated Stereogenic Centers: The Bisai Synthesis of Lycoramine
Pher G. Andersson of Stockholm University showed that a Z/E mixture of the enone 1 could be hydrogenated to 2 in high ee (Nature Commun. 2022, 13, 361. DOI: 10.1038/s41467-022-28003-6).…
Diels-Alder Cycloaddition: δ-Cadinol (Schulz), KB343 (Baran), Penostatin C (Chen), Senopodine E (Ishikawa), Vermisporin (Lei), Kibdelomycin (Schobert)
Stefan Schulz of the Technische Universität Braunschweig updated the classic intramolecular Diels-Alder cycloaddition of the triene 1 to the ketone 2, readily convertible to δ-cadinol (3), by preparing 1 via…
Reduction: The Ichikawa/Hosokawa Synthesis of Axisonitrile-3
Liang-Nian He of Nankai University and Chao-Jun Li of McGill University converted the hydrazone of carvone 1 to the triene 2 (JACS Au 2022, 2, 1929. DOI: 10.1021/jacsau.2c00320). Mathias Schelwies…
Best Synthetic Methods: Oxidation
Efficient new methods for oxidation are always welcome. The Dess-Martin periodinane has become the workhorse for alcohol to aldehyde or ketone conversion in organic research labs around the world. 5-Azaspirooctane-6,8-dione…
Alkylated Stereogenic Centers: The Zakarian Synthesis of Goniomitine
Xufeng Lin of Zhejiang University used an enantiomerically-pure bis iodide to mediate the oxidative cyclization of the prochiral amine 1 to the lactam 2 (Tetrahedron Lett. 2022, 109, 154157. DOI:…
Synthesis of (-)-Podophyllotoxin
(-)-Podophyllotoxin 1 and its derivative etoposide 2, derived from natural sources, are in current clinical use. Michael Sherburn of Australian National University reports (J. PMID:23618405 Am. 2-Methylpyrimidine-5-carbaldehyde custom synthesis Chem.…
Nt (Table S1 from the Supporting Facts). The omit density map
Nt (Table S1 in the Supporting Information and facts). The omit density map shows a single Mn(II) ion (Mn1) within a tetrahedral coordination complex with three amino acid residues (Cys98,…
:10.1371/journal.pone.0079682.tPLOS 1 | www.plosone.orgHeritability of Uremic Retention MoleculesTable
:10.1371/journal.pone.0079682.tPLOS 1 | www.plosone.orgHeritability of Uremic Retention MoleculesTable two. Baseline qualities by quartiles of pcresyl sulfate.PCresyl Sulfate, mmol/L Characteristics Qualities n ( ) Males Hypertension Antihypertensive drug intake Diabetes mellitus…
Heteroaromatics: The Zhu Synthesis of Anibamine B
Kegong Ji of the Northwest Agricultural & Forestry University used a Cu catalyst to cyclize the alkyne 1 to the furan 2 (Org. 8-Hydroxyoctanoic acid In stock Chem. Front. 2023,…