The Overman Route to Gelsemine
Chemexpress Gelsemine 3 has no particular biological activity that recommends it, but its challenging architecture has been a motivation to a generation of organic synthesis chemists. Larry E. Overman of the…
Synthesis of (-)-Littoralisone
The loss of mental function associated with aging is thought to be due at least in part to the degradation of neurite connections between neurons. Natural products such as (-)-littoralisone…
Synthesis and Absolute Stereochemical Assignment of (-)-Galbulimima Alkaloid 13
The galbulimima alkaloids have intriguing physiological activity, but the absolute configuration of glabulimima alkaloid 13 (3) had not been assigned. Mohammad Movassaghi of the Massachusetts Institute of Technology has developed…
The Stork Synthesis of (-)-Reserpine
The history of reserpine (3), isolated from the Indian shrub Rauwolfia serpentina, is storied. The anxiolytic activity of reserpine, the first tranquilizer, pointed the way to the development by Hoffmann-LaRoche…
He quantity of second generation folks inside a brood decreased with
He number of second generation people inside a brood decreased with rising concentration of pyroproxyfen (Fig. 7E) suggesting that pyriproxyfen decreased the number of oocytes recruited for maturation or elevated…
Hat YGTSS tic severity was greater for youth withFIG. 1. Breakdown of
Hat YGTSS tic severity was higher for youth withFIG. 1. Breakdown of Diagnostic Interview Schedule for Children (DISC)generated tic disorder diagnosis for youth and parent respondents.UTILITY Of the DISC FOR…
Alkene metathesis in total synthesis: Valienamine, Agelastatin and Tonantzitlolone
Applications to natural product synthesis probe the limits of any synthetic method, as situations arise that would never have been considered in the course of first developing the method. PMID:35567400…
Best Synthetic Methods: Oxidation and Reduction
Although oxidation and reduction are common organic synthesis transformations, there is always room for improvement. The ideal reaction might use a solid, easily-measured reagent, a minimal amount of solvent, need…
Formation of Aromatic-Amino and Aromatic-Carbon Bonds
The formation of bonds to aromatic rings is the foundation of much of organic synthesis. There has been much excitement over the past several years around Pd- or Cu-mediated displacement…
Protection of N- and O-Functional Groups
O– and N-protection is often necessary in organic synthesis. Several recent advances in functional group protection-deprotection are particularly noteworthy. Formula of (S)-4-(1-Aminoethyl)phenol hydrobromide Primary benzenesulfonamides have been notoriously difficult to…