Nitrogen heterocycles are the basis of many essential pharmaceuticals, and of many physiologically-active natural products. There is a continuing interest in the development of new methods for the construction of…
There are several strategies now available for the catalytic construction of isolated oxygenated and aminated stereogenic centers in high enantiomeric excess (2006 Jan 9). Processes for the catalytic enantioselective construction…
Thomas J. J. Müller of the Universität Heidelberg has reported (Chem. Methyltrioxorhenium(VII) structure 5-(Thiazol-5-yl)nicotinic acid web Commun. 2005, 2581.DOI: 10.1039/b502324f)a powerful method for the assembly of highly substituted furans, Pd-mediated…
Enantiomerically-pure carbocycles can be prepared either de novo, or by desymmetrization of prochiral rings. A classic illustration of the latter approach is the condensation of cyclohexanone (1) with p-nitrobenzaldehyde (2).…
Homoallylic secondary alcohols such as 1 are readily prepared in enantiomerically-pure form by enantioselective addition of allyl anions to the aldehyde. Subhas Chandra Roy of the Indian Association for the…
The Strecker synthesis is the one-carbon homologation of an aldehyde to the α-amino nitrile. Robert Cunico of Northern Illinois University in DeKalb reports (Tetrahedron Lett. 2003, 44, 8025.DOI: 10.1016/j.tetlet.2003.09.006)a modified…
Keiji Maruoka of Kyoto University has developed highly selective catalysts for the alkylation of protected glycine anions. PMID:23600560 He has now shown (J. Am. Chem. Soc. 2005, 127, 5073.DOI: 10.1021/ja0459328)that…
Aryl amines are common constituents of pharmaceuticals, so there has been a great deal of interest in their preparation, e.g by Pd- or Cu-mediated amination of aryl halides. Multi-step procedures…
Alkene metathesis (“Grubbs Reaction”) is now well-developed as a synthetic method. Still, there is a continuing effort to develop more efficient catalysts, and to extend the range of substrates that…
Selective halogenation can be a direct route to high value added materials from inexpensive hydrocarbons. José Barluenga of the Universidad de Oviedo has developed (Angew. Chem. Int. Ed. PMID:23514335 2005,…
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