In the chemistry described below, Coats and a group of researchers from Johnson and Johnson utilized successive reductive aminations and Suzuki cross coupling reactions to prepare a 192-member library of…
A small library of 2,4(1H,3H)-quinazolinediones (X = O) and 2-thioxoquinazolines (X = S) was prepared via the reaction of substituted methyl anthranilate with diverse iso(thio)cyanates without the addition of catalyst,…
The group of Stefan Bräse from the University of Karlsruhe has performed optimization studies toward solvent, time, temperature and catalyst loading for the microwave-mediated organocatalytic asymmetric α-amination of disubstituted aldehydes…
John Walton and co-workers from the University of St. Andrews, UK, have reported on the use of O-phenyl oxime ethers as precursors for iminyl radicals en route for N-heterocycle synthesis…
The synthesis of 1,2,3-triazoles via Ru-catalyzed aryl azide-alkyne cycloadditions was described by the group of Valery Fokin from The Scripps Research Institute (Org. Lett. 2007, 9, 5337. DOI: 10.1021/ol701912s). PMID:35991869…
The intramolecular cycloaddition of alkenyl- (1) and aryl-substitued 1,6-enynes 2 was described by the group of Antonio Echavarren from the Institute of Chemical Research of Catalonia (ICIQ), Spain, (J. PMID:25046520…
Ng the initiation of lesion development43. For that reason, it can’t be excluded that ADAM8 may well have an impact at earlier developmental stages, since all atherosclerotic lesions in this…
Ine RegorafenibaHypertension (calcium channel) HIV (reverse transcriptase) HIV (reverse transcriptase) Hypertension (calcium channel) Hypertension (calcium channel) Leukemia (tyrosine kinase) Thyroid cancer (tyrosine kinase) Prostate cancer (CYP17A1) Hypertension (angiotensin II receptor)…
The groups of Vladimir Gevorgyan and Valery Fokin from the University of Illinios and The Scripps Research Institute have reported on the synthesis of imidazoles via the transannulation of 1-sulfonyl…
Both 1 and 3 are inexpensive prochiral starting materials. Tae-Jong Kim of Kyungpook National University devised (Organomet. 2008, 27, 1026.DOI: 10.1021/om700935m) a chiral Cu catalyst that efficiently converted 1 (other…
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