Rapamycin (3) is used clinically as an immunosuppressive agent. The synthesis of 3 (Angew. N-(2-Hydroxyethyl)maleimide Data Sheet Chem. Int. PMID:35345980 Morpholin-2-one site Ed. 2007, 46, 591.DOI: 10.1002/anie.200604053)by Steven V. Ley…
Cruentaren A (3), isolated from the myxobacterium Byssovorax cruenta, is an inhibitor of mitochondrial F-ATPase. The synthesis of 3 (Org. Lett. 2007, 9, 655, DOI: 10.1021/ol0629317; Angew. Chem. Int. Ed.…
(+)-Superstolide A (3), isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at ~ 4 ng/mL concentration. The key transformation in the synthesis of…
Ome 22 (nucleotide 17,049,3907,056,254, 6,865 bp, GEO accession quantity for the aCGH is GEO: GSE89191; Supplementary Information). These cytogenetic observations helped interpret quantitative measurements of codon 707 mutations by dPCR.…
Es (, , and MSH) are a loved ones of peptide hormones that regulate skin pigment cells and impact a array of other processes within the physique, including decreasing inflammation…
A recent publication by the group of Phil S. Baran from the Scripps Research Institute (Angew. Formula of 3-Vinylthiophene Chem. Int. Ed. PMID:24268253 2004, 43, 2674. DOI: 10.1002/anie.200453937) reports the…
The sulfate (+)-didemniserinolipid B (3), isolated from the tunicateDidemnum sp, has an intriguing spiroether core. 1-Bromo-2-fluorobenzene Chemscene A key step in the synthesis of 3 reported (Org. PMID:25046520 Lett. 1031967-52-8…
(+)-Discodermolide (3), a potent anticancer agent that works synergistically with taxol, may yet prove to be clinically effective. For the synthetic material to be affordable, a highly convergent synthesis is…
(-)-Cernuine (3) falls in the subset of the Lycopodium alkaloids that feature a bicyclic aminal core. There had not been a total synthesis of this class of alkaloids until the…
The tetracyclic Lycopodium alkaloid fawcettimine (3) and its derivatives are of interest as inhibitors of acetylcholine esterase. F. Dean Toste of the University of California, Berkeley recently reported (Angew. Chem.…
Chemexpress