The Maier Synthesis of Cruentaren A
Chemexpress Cruentaren A (3), isolated from the myxobacterium Byssovorax cruenta, is an inhibitor of mitochondrial F-ATPase. The synthesis of 3 (Org. Lett. 2007, 9, 655, DOI: 10.1021/ol0629317; Angew. Chem. Int. Ed.…
The Roush Synthesis of (+)-Superstolide A
(+)-Superstolide A (3), isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at ~ 4 ng/mL concentration. The key transformation in the synthesis of…
Ome 22 (nucleotide 17,049,3907,056,254, six,865 bp, GEO accession number for the aCGH is GEO
Ome 22 (nucleotide 17,049,3907,056,254, 6,865 bp, GEO accession quantity for the aCGH is GEO: GSE89191; Supplementary Information). These cytogenetic observations helped interpret quantitative measurements of codon 707 mutations by dPCR.…
Es (, , and MSH) are a family of peptide hormones that regulate
Es (, , and MSH) are a loved ones of peptide hormones that regulate skin pigment cells and impact a array of other processes within the physique, including decreasing inflammation…
Vinyl Cyclobutane Rearrangements
A recent publication by the group of Phil S. Baran from the Scripps Research Institute (Angew. Formula of 3-Vinylthiophene Chem. Int. Ed. PMID:24268253 2004, 43, 2674. DOI: 10.1002/anie.200453937) reports the…
The Betzer and Ardisson Synthesis of (+)-Discodermolide
(+)-Discodermolide (3), a potent anticancer agent that works synergistically with taxol, may yet prove to be clinically effective. For the synthetic material to be affordable, a highly convergent synthesis is…
The Burke Synthesis of (+)-Didemniserinolipid B
The sulfate (+)-didemniserinolipid B (3), isolated from the tunicateDidemnum sp, has an intriguing spiroether core. 1-Bromo-2-fluorobenzene Chemscene A key step in the synthesis of 3 reported (Org. PMID:25046520 Lett. 1031967-52-8…
The Takayama Synthesis of (-)-Cernuine
(-)-Cernuine (3) falls in the subset of the Lycopodium alkaloids that feature a bicyclic aminal core. There had not been a total synthesis of this class of alkaloids until the…
The Toste Synthesis of (+)-Fawcettimine
The tetracyclic Lycopodium alkaloid fawcettimine (3) and its derivatives are of interest as inhibitors of acetylcholine esterase. F. Dean Toste of the University of California, Berkeley recently reported (Angew. Chem.…
C-H Functionalization: The White Reagent
The direct functionalization of a C-H bond is a powerful transformation for organic synthesis, allowing the rapid elaboration of desired complexity from inexpensive starting materials. Formula of (3-Hydroxy-5-methylphenyl)boronic acid Even…