The Keck Synthesis of Epothilone B
Chemexpress The total synthesis of Epothilone B (4), the first natural product (with Epothilone A) to show the same microtubule-stabilizing activity as paclitaxel (Taxol®), has attracted a great deal of attention…
The Davies/Williams Synthesis of (-)-5-epi-Vibsanin E
There are currently 61 known vibsane-type diterpenes, as exemplified by (-)-5-epi-Vibsanin E (3). The first synthesis of 3, described (J. Price of 79208-84-7 Am. Chem. Soc. 2009, 131, 8329. DOI:…
The Hoveyda Synthesis of (-)-Clavirolide C
Conjugate addition-enolate trapping, a strategy originally developed by Gilbert Stork, has become a powerful method for stereocontrolled ring construction. A key step in the synthesis of (-)-Clavirolide C (3) reported…
Enantioselective C-C Bond Construction: Part One of Three
The enantioselective addition of allyl organometallics to carbonyls has become one of the workhorses of organic synthesis. PMID:24318587 Dennis Hall of the University of Alberta reports (J. Am. Chem. Soc.…
Cells to insoluble purple formazan dye crystals. One hundred microliters per
Cells to insoluble purple formazan dye crystals. One hundred microliters per nicely of dimethyl sulfoxide (DMSO) was employed for the soluble crystals, along with the absorbance was study using a…
Had been morphometrically analyzed by measuring the total emptied region standardized over
Were morphometrically analyzed by measuring the total emptied location standardized over the total tissue location. Briefly, the outer border in the spinal cord section was identified to delineate the website…
Part 3: Facile synthesis of amines, amides, imines and hydrazones promoted by ultrasound irradiation
High yielding ultrasound mediated three-component synthesis of substituted propargylamines Sreedhar and co-workers from Indian Institute of Chemical Technology have described a mild one-pot, three-component synthesis of substituted propargylamines by using…
The Wood Synthesis of Welwitindolinone A Isonitrile
Welwitindolinone A Isonitrile (3) is the first of a family of oxindole natural products isolated from the cyanobacteria Hapalosiphon welwischii and Westiella intricate on the basis of their activity for…
The Castle Synthesis of (-)-Acutumine
The complex tetracyclic alkaloid (-)-acutumine 3, isolated from the Asian vine Menispermum dauricum, shows selective T-cell toxicity. The two adjacent cyclic all-carbon quaternary centers of 3 offered a particular challenge.…
The Carter Synthesis of (-)-Lycopodine
Rich G. PMID:23381626 Carter of Oregon State University described (J. Am. Chem. Soc. 2008, 130, 9238 DOI: 10.1021/ja803613w) the first enantioselective synthesis of the Lycopodium alkaloid (-)-lyopodine (3). A key…