The construction of carbon-carbon bonds is fundamental to organic synthesis. PMID:23880095 Recently, three new methods have been reported, each of which has substantial potential for the synthesis of highly functionalized…
The enantioselectivity of alkene reduction usually depends on the geometric purity of the alkene. Bruce H. Lipshutz of the University of California, Santa Barbara used (Org. Lett. 2007, 9, 4713.DOI:…
Armando Córdova of Stockholm University has found (Tetrahedron Lett. 2008, 49, 4209. DOI: 10.1016/j.tetlet.2008.04.162)that the organocatalyst 3a effected enantioselective conjugate addition of bromonitromethane 2 to the α,β-unsaturated aldehyde 1, to…
Often, 6,6-spiroketals such as Spirofungin A (3) have a strong anomeric bias. Spirofungin A does not, as the epimer favored by double anomeric stabilization suffers from destabilizing steric interactions. Tetrabutylammonium…
Lograft is shown. (D.) CD8+CD122+PD-1+ Tregs isolated from na e B6 mice mainly expressed FasL prior to their adoptive transfer, as determined by flow analyses. One particular of two separate…
The polyene macrolide RK-397 (3), isolated from soil bacteria, has antifungal, antibacterial and anti-tumor activity. Tarek Sammakia of the University of Colorado has described (Angew. 1-Acetoxy-1,2-benziodoxol-3-(1H)-one site Chem. PMID:23546012 Int.…
The monoterpene alkaloid (-)-incarvillateine (3) has interesting symmetry properties. The centralcyclobutane diacid core is not itself chiral, but the appended alkaloids are. The key step in the total synthesis of…
The pentacyclic alkaloid (+)-lyconadin A (3), isolated from the club moss Lycopodium complanatum, showed modest in vitro cytotoxicity. A key step in the first reported (J. PMID:23805407 Am. Chem. Soc.…
The macrolactone leucascandrolide A (4), isolated from the calcareous sponge L. caveolata, has both cytotoxic and antifungal activity. The key step in the synthesis of 4 reported (J. Org. Chem.…
Rapamycin (3) is used clinically as an immunosuppressive agent. The synthesis of 3 (Angew. N-(2-Hydroxyethyl)maleimide Data Sheet Chem. Int. PMID:35345980 Morpholin-2-one site Ed. 2007, 46, 591.DOI: 10.1002/anie.200604053)by Steven V. Ley…
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