The Magnus Synthesis of (±)-Codeine
Chemexpress Although there have been many synthetic approaches to morphine and its methyl ether codeine (3), the pentacyclic structure of these Papaver alkaloids continues to intrigue organic chemists. Philip Magnus of…
The Baran Synthesis of Vinigrol
The diterpene vinigrol (3), isolated from Virgaria nigra F-5408, has eluded total synthesis for more than twenty years. 1403257-80-6 manufacturer Attempts to construct the four-carbon bridge on a preformed cis-decalin…
D arabinose accounted for the remaining 30 ofBacterioplankton-specific growth rates were considerably
D arabinose accounted for the remaining 30 ofBacterioplankton-specific development prices have been drastically larger only within the Amansia amendments (1.1 1 per day), whereas other treatments and controls ranged from…
An tissues (MTC panel human I, Clontech) was amplified by PCR
An tissues (MTC panel human I, Clontech) was amplified by PCR applying ARSK-specific primers (forward primer five -TTA ATT CAT CTG GAT CCG AGG AAA G-3 and reverse primer five…
The Chen Synthesis of (-)-Nakiterpiosin
(-)-Nakiterpiosin (3), isolated from the thin encrusting sponge Terpios hoshinota, has an IC50 against murine P388 leukemia cells of 10 ng/mL. Chuo Chen of UT Southwestern Medical Center developed (J.…
The Nicolaou Synthesis of (+)-Hirsutellone B
(+)-Hirsutellone B (3), isolated from the insect pathogenic fungus Hirsutella nivea BCC 2594, shows good activity (MIC = 0.78 μg/mL) against Mycobacterium tuberculosis. Approaching the synthesis of 3, K. Val-cit-PAB-OH…
The Overman Synthesis of Briarellin F
Briarellin F (4) is an elegant representative of the complex polycyclic ethers produced by soft corals such as Briareum abestinum. Larry E. Overman of the University of California, Irvine developed…
The Corey Synthesis of (+)-Lupeol
The total synthesis of lupeol was one of the crowning achievements of the Robinson annulation/reductive alkylation approach to stereocontrolled polycarbocyclic construction developed by Gilbert Stork (J. Am. Chem. Soc. 1971,…
The Williams Synthesis of (-)-4-Hydroxydictyolactone
(-)-4-Hydroxydictyolactone (3), representative of the cyclononene xenicanes isolated from the Dictyotacae algae, readily isomerizes thermally to the more stable (Z)-6,7-isomer. Attempts to directly form this strained ring system appeared to…
Biocatalytic Asymmetric Hydrogen Transfer
Bioreductions and biooxidations, although they can be highly selective, have often been limited by the requirement for expensive reducing or oxidizing biological cofactors. PMID:23626759 Wolfgang Kroutil of the University of…