The push toward enantiomerically-purecarbocyclic intermediates has led to the development of new methods for the enantiodifferentiation of inexpensive prochiral cyclic starting materials. For instance, Robert H. Morris of the University…
In the last few years, chiral sulfoxides have become important targets in organic synthesis, and their chemistry has recently been reviewed (Org. Chem. Highlights 2004, December 24. Link). An increasing…
The asymmetric conjugate addition is regarded as one of the most powerful tools for the selective formation of chiral C-C or C-X bonds. Particular cases of this methodology are the…
Weaker and longer than covalent linkages, hypervalent bonds are the result of a linear three-center, four-electron (3c-4e) electronic distribution (hypervalent model). PMID:23927631 Hypervalent iodine reagents are useful synthetic tools due…
The aldol addition reaction is one of the most versatile, effective and general methods for the formation of C-C bonds in modern organic synthesis. The challenge raised by nature has…
The enantioselective construction of aminated stereogenic centers is a central task both for pharmaceutical production and for alkaloid synthesis. Activated aziridines should be as useful as epoxides for carbon-carbon bond…
Water plays an essential role in life processes, however its use as a solvent has been limited in organic synthesis. Despite the fact that it is the cheapest, safest and…
The use of boranes in a promising experimental approach to cancer treatment is one of the most challenging current targets of medicinal chemistry. Fmoc-8-amino-3,6-dioxaoctanoic acid web Amine-carboxyboranes Amine-carboxyboranes (A•BH2COOH) are…
Hanced Kir6.two signal in the cell periphery, but this leptin impact was significantly inhibited by CC (Fig. 2E). For quantitative analysis, the ratio of peripheral to total Kir6.2 signal was…
Uncommon genetic variations, contributed for the divergent HERV responses and variable responses to injury. Particularly, patientspecific genomic HERVs may perhaps play a role, at least in aspect, inside the variable…
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