Takahata), Elatol (Stoltz), 5-F2t-Isoprostane (Snapper), and Ottelione B (Clive) Alkene metathesis has been used to prepare more and more challenging natural products. The first and second generation Grubbs catalysts 1…
Alcohols are usually protected as alkyl or silyl ethers. PMID:23626759 Michael P. Jennings of the University of Alabama found (Tetrahedron Lett. 2008, 49, 5175 DOI: 10.1016/j.tetlet.2008.06.072) that pyridinium tribromide can…
Several elegant methods for the enantioselective transformation of preformed prochiral rings have been put forward. Derek R. Boyd of Queen’s University, Belfast devised(Chem. PMID:28739548 Commun. 2008, 5535.DOI: 10.1039/b814678k)a Cu catalyst…
As the computational methods used in pharmaceutical development have improved, receptor binding analysis has led to many potential new drug candidates that are polycyclic. N-Boc-PEG6-alcohol Data Sheet Such leads are…
(+)-Bruguierol A (Fañanás/Rodríguez), (-)-Berkelic Acid (Snider), and (-)-Aigialomycin D (Harvey) (+)-Conocarpan (3), isolated from the wood of Conocarpus erectus, exhibits insecticidal, antifungal and antitrypanosomal activity. Shunichi Hashimoto of Hokkaido University…
Te the theoretical partnership between HDL size as well as the HDL-C/ApoA-I ratio and to provide estimates of HDL-P. Facts are supplied within the Supplemental Data. Non-linear algebraic equations from…
As utilized because the criterion for significance in replication analyses to maximize statistical energy.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptResultsPreliminary Analyses Inspection of genotyping outcomes from good controls…
In the context of peptidyl ketone synthesis, Troels Skrydstrup of the University of Aarhus developed (J. Org. PMID:24377291 Chem. 2008, 73, 1088. DOI: 10.1021/jo702286b) the elegant SmI2-mediated conjugate addition of…
Enzymatic reduction of a ketone can proceed in high enantiomeric excess, but this would require a stoichiometric amount of a reducing agent. Wolfgang Kroutil of the Karl-Franzens-Universität Graz devised (Angew.…
Hervé Clavier and Steven P. Nolan, now at St. Andrew’s University, found (Adv. Synth. Catal. 2008, 350, 2959.DOI: 10.1002/adsc.200800495)that the indenylidene Ru complex 1 was an excellent pre-catalyst for alkene…
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