Alkylated Sterogenic Centers: The Nagamitsu Synthesis of Habiterpenol
Chemexpress Chihui An and Megan H. Shaw of Merck Process achieved high ee in the reduction of the α-methylene acid 1 to the α-methyl acid 2 (Org. Lett. 2020, 22, 8320.…
(TMS)3SiH in organic synthesis: Part 1
The radical chemistry associated with organosilanes has been the subject of my recent book (Chatgilialoglu C. Organosilanes in Radical Chemistry; Wiley: Chichester, 2004). 7-Chloropyridopyrazine In stock In particular, the use…
Total Synthesis of Ingenol
The total synthesis of the tetracyclic Euphorbia tetraol ingenol 3 reported by Keiji Tanino of Hokkaido University (J. Am. Chem. Soc. PMID:23290930 (1-Methyl-1H-imidazol-2-yl)methanamine web 2003, 125, 1498.DOI: 10.1021/ja029226n)illustrates the power…
Synthesis of (-)-Podophyllotoxin
(-)-Podophyllotoxin 1 and its derivative etoposide 2, derived from natural sources, are in current clinical use. 1239319-91-5 site Michael Sherburn of Australian National University reports (J. Am. PMID:23543429 Chem. Soc.…
Total Synthesis of Ingenol
The total synthesis of the tetracyclic Euphorbia tetraol ingenol 3 reported by Keiji Tanino of Hokkaido University (J. PMID:28630660 Am. 6-Fluoro-2,3-dihydrobenzofuran site Chem. 2832911-62-1 Data Sheet Soc. 2003, 125, 1498.DOI:…
(TMS)3SiH in organic synthesis: Part 1
The radical chemistry associated with organosilanes has been the subject of my recent book (Chatgilialoglu C. Organosilanes in Radical Chemistry; Wiley: Chichester, 2004). PMID:24605203 In particular, the use of(TMS)3SiH in…
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