Product Name :
SOD2 Recombinant Rabbit Monoclonal Antibody [JJ089-02]
Predicted band size :
25 kDa
Observed band size :
23 kDa
Synonyms:
Indophenoloxidase B antibody IPO B antibody IPOB antibody Manganese containing superoxide dismutase antibody Manganese SOD antibody Manganese superoxide dismutase antibody Mangano superoxide dismutase antibody Mn SOD antibody Mn superoxide dismutase antibody MNSOD antibody 展开
Function :
The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. The SOD-2 precursor is a 222 amino acid protein that is encoded by nuclear chromatin, synthesized in the cytosol and imported posttranslationally into the mitochondrial matrix. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. ROS are implicated in a wide range of degenerative processes, including Alzheimer’s disease, Parkinson’s disease and ischemic heart disease. Homozygous mutant mice, which lack SOD-2, exhibit dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, metabolic acidosis, oxidative DNA damage and respiratory chain deficiencies in heart and skeletal muscle. Polymorphisms in the SOD-2 gene have also been implicated in nonfamilial, idiopathic, dilated cardiomyopathy in humans.147969-86-6 web
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human SOD2 aa 1-50 / 222.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JJ089-02
RRID:
AB_3073464
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.5-Bromo-1,3,4-thiadiazole-2-carbaldehyde Chemscene Aliquot store at -20℃ or -80℃.PMID:33615823 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 25 kDa
Positive control :
Mouse brain tissue lysate, SH-SY5Y cell lysate, mouse heart tissue lysate, human liver tissue, human kidney tissue, mouse liver tissue, mouse colon tissue, mouse heart tissue.