Product Name :
N-Cadherin Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CADH2_HUMAN antibody Cadherin 2 antibody Cadherin 2 N cadherin neuronal antibody Cadherin 2 type 1 antibody Cadherin 2 type 1 N cadherin neuronal antibody Cadherin 2, type 1, N-cadherin (neuronal) antibody Cadherin-2 antibody Cadherin2 antibody Calcium dependent adhesion protein neuronal antibody CD325 antibody 展开
Function :
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide corresponding to Human N-Cadherin aa 391-440 / 906 (H412G).849805-25-0 uses
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC, IF, ELISA
Coupling :
unconjugated
Clone number:
RRID:
AB_3069012
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
-15℃ to -25℃/1 year(Do not lower than -25℃)
Storage buffer solution:
1*PBS (pH7.8-Hydroxyoctanoic acid supplier 4), 0.PMID:33599243 2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 100 kDa
Positive control :
Brain,Epithelium,Liver