Product Name :
2′/3′-O-Acetyl ADP Ribose (CAS 1312013-29-8)
Synonym :
2′/3′-O-Acetyl ADP Ribose is known as protein deacetylated NAD metabolites.
Application :
2′/3′-O-Acetyl ADP Ribose is a metabolite product of the sirtuin-mediated protein deacetylation of Nicotinamide adenine dinucleotide.
CAS:
1312013-29-8
Purity:
Molecular Weight:
645.32
Formula :
C17H23N5Na2O15P2
Physical state:
Solid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
157-160° C (dec.)
SMILES:
References:
:Structural identification of 2′- and 3′-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases. | Jackson, MD. and Denu, JM. 2002. J Biol Chem. 277: 18535-44. PMID: 11893743Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. | Khan, JA., et al. 2007. Expert Opin Ther Targets. 11: 695-705. PMID: 17465726Sirtuins: novel targets for metabolic disease. | Elliott, PJ. and Jirousek, M. 2008. Curr Opin Investig Drugs. 9: 371-8. PMID: 18393104CobB1 deacetylase activity in Streptomyces coelicolor.1209487-56-8 web | Mikulik, K.1-Methylcyclobutanecarboxylic acid manufacturer , et al.PMID:33617666 2012. Biochem Cell Biol. 90: 179-87. PMID: 22300453Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity. | Pirrie, L., et al. 2012. Molecules. 17: 12206-24. PMID: 23079492Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain. | Haikarainen, T. and Lehtiö, L. 2016. Sci Rep. 6: 24213. PMID: 27064071Chemical and Physiological Features of Mitochondrial Acylation. | Ringel, AE., et al. 2018. Mol Cell. 72: 610-624. PMID: 30444998Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing. | Reiten, OK., et al. 2021. Mech Ageing Dev. 199: 111567. PMID: 34517020