Histology of proximal tibia showed important decreases in MS/BS, MAR and BFR/BS in the OVX rats compared with the sham, plus the CFE group totally maintained these parameters for the…
Lbeit to a lesser extent than with phenformin, and DHAP and glyceraldehyde3phosphate are slightly decreased. Neither biguanide has an impact around the earliest glycolytic intermediates that are elevated during transformation…
Pher G. Andersson of Stockholm University showed that a Z/E mixture of the enone 1 could be hydrogenated to 2 in high ee (Nature Commun. 2022, 13, 361. DOI: 10.1038/s41467-022-28003-6).…
Jin-Na Song of Jilin University and Yongquan Ning of Northeast Normal University assembled the furan 3 by combining the diazoalkane derived in situ from the tosylhydrazone 2 with the β-keto…
Liang-Nian He of Nankai University and Chao-Jun Li of McGill University converted the hydrazone of carvone 1 to the triene 2 (JACS Au 2022, 2, 1929. DOI: 10.1021/jacsau.2c00320). Mathias Schelwies…
Stefan Schulz of the Technische Universität Braunschweig updated the classic intramolecular Diels-Alder cycloaddition of the triene 1 to the ketone 2, readily convertible to δ-cadinol (3), by preparing 1 via…
Xufeng Lin of Zhejiang University used an enantiomerically-pure bis iodide to mediate the oxidative cyclization of the prochiral amine 1 to the lactam 2 (Tetrahedron Lett. 2022, 109, 154157. DOI:…
Efficient new methods for oxidation are always welcome. The Dess-Martin periodinane has become the workhorse for alcohol to aldehyde or ketone conversion in organic research labs around the world. 5-Azaspirooctane-6,8-dione…
(-)-Podophyllotoxin 1 and its derivative etoposide 2, derived from natural sources, are in current clinical use. Michael Sherburn of Australian National University reports (J. PMID:23618405 Am. 2-Methylpyrimidine-5-carbaldehyde custom synthesis Chem.…
Nt (Table S1 in the Supporting Information and facts). The omit density map shows a single Mn(II) ion (Mn1) within a tetrahedral coordination complex with three amino acid residues (Cys98,…
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